Desirable attributes of vaccines for deployment in low-resource settings
Desirable attributes of vaccines for deployment in low-resource settings
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DOI：
10.1002/jps.23352
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发表时间：
2013-01-01
影响因子：
3.8
通讯作者：
Zehrung, Darin
中科院分区：
文献类型：
--
作者：
Chen, Dexiang;Zehrung, Darin
一些产品开发伙伴关系正在积极开发新疫苗，以防治发展中国家的传染病。为了有效，正在开发的产品不仅应该安全、有效和负担得起，而且还应该具有额外的理想技术属性，包括增强的稳定性、有效的包装和更容易交付。现在有新技术可以实现这些属性;然而，许多技术尚未被疫苗行业采用。本评论讨论了与推进这些属性相关的机遇和挑战，特别是疫苗热稳定性和剂量节省策略，以及必须解决的关键问题，以弥合技术开发和产品开发之间的差距。(c)2012 Wiley Periodicals，Inc.和American Pharmacologist Association J Pharm Sci 102：2933，2013
A number of product development partnerships are actively developing new vaccines to combat infectious diseases in developing countries. To be effective, the products under development should not only be safe, efficacious, and affordable, but they should also have additional desirable technical attributes, including enhanced stability, efficient packaging, and improved ease of delivery. New technologies are now available to achieve these attributes; however, many of the technologies have yet to be adopted by the vaccine industry. This commentary discusses the opportunities and challenges associated with advancing such attributes, especially vaccine thermostability and dose sparing strategies, and the critical issues that must be addressed to bridge the gap between technology development and product development. (c) 2012 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 102:2933, 2013