Two-year longitudinal study of parotid salivary flow rates in head and neck cancer patients receiving unilateral neck parotid-sparing radiotherapy treatment
Two-year longitudinal study of parotid salivary flow rates in head and neck cancer patients receiving unilateral neck parotid-sparing radiotherapy treatment
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DOI：
10.1016/s1368-8375(98)00104-3
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发表时间：
1999-05-01
期刊：
影响因子：
4.8
通讯作者：
Ship, JA
中科院分区：
文献类型：
--
作者：
Henson, BS;Eisbruch, A;Ship, JA
放射治疗 (RT) 是头颈癌的常见治疗方法，经常导致永久性唾液功能障碍和口干症。这项为期 2 年的纵向研究评估了 11 名接受单侧颈部腮腺保留放疗的头颈癌患者未刺激和刺激时的腮腺流量。结果表明，接受治疗的腮腺在 RT 后 2 年内基本上没有输出。或者，在 RT 后 1 年和 2 年时，幸存的腮腺流速与 RT 前值没有区别，并且随着时间的推移略有增加。完成 RT 后 2 年，未刺激和刺激的腮腺总弓率与 RT 前的值相似，表明保留的腮腺功能可以补偿治疗后腮腺功能的丧失。这些结果表明，单侧颈部腮腺保留技术在 RT 完成后 2 年内可有效保留对侧腮腺。 (C) 1999 Elsevier Science Ltd. 保留所有权利。
Radiotherapy (RT) is a common treatment: for head and neck cancers, and frequently causes permanent salivary dysfunction and xerostomia. This 2-year longitudinal study evaluated unstimulated and stimulated parotid flow rates in 11 patients with head and neck cancers who received unilateral neck parotid-sparing RT. The results demonstrated that treated parotid glands had essentially no output up to 2 years post-RT. Alternatively, spared parotid flow rates were indistinguishable from pre-RT values at I and 2 years post-RT, and increased slightly over time. Total unstimulated and stimulated parotid Bow rates 2 years after completion of RT were similar to pre-RT values, suggesting that spared parotid function may compensate for lost function from treated parotid glands. These results demonstrate that unilateral neck parotid-sparing techniques are effective in preserving contralateral parotid glands up to 2 years after the completion of RT. (C) 1999 Elsevier Science Ltd. All rights reserved.