The Multifaceted Roles of CXCL9 Within the Tumor Microenvironment
The Multifaceted Roles of CXCL9 Within the Tumor Microenvironment
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DOI：
10.1007/978-3-030-36667-4_5
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发表时间：
2020-01-01
期刊：
影响因子：
--
通讯作者：
Lundqvist, Andreas
中科院分区：
文献类型：
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作者：
Neo, Shi Yong;Lundqvist, Andreas
趋化因子是一种可溶性蛋白，在一定的浓度梯度下调控细胞迁移。在肿瘤发展的早期阶段，趋化因子塑造了肿瘤微环境的免疫景观。CXCL9，也被称为γ -干扰素（MIG）诱导的单因子，可在炎症条件下由肿瘤微环境中的骨髓细胞产生。它吸引表达CXCR3受体的细胞，包括活化的T细胞和NK细胞，并已被证明在免疫检查点治疗的应答中发挥作用。过度表达CXCL9也显示通过抑制血管生成来减少肿瘤进展和转移。相反，CXCL9可以直接作用于表达CXCR3受体的肿瘤细胞，促进细胞迁移和上皮间质转化。在本章中，我们讨论了CXCL9在肿瘤微环境中的抗肿瘤和促肿瘤特性。
Chemokines are soluble proteins that orchestrate cell migration in a regulated concentration gradient. During early stages of tumor development, chemokines shape the immune landscape of tumor microenvironment. CXCL9, also known as monokine induced by gamma-interferon (MIG), can be produced during inflammatory conditions by myeloid cells within the tumor microenvironment. It attracts cells expressing the CXCR3 receptor including activated T and NK cells and has been shown to play a role in responses to immune checkpoint therapy. Overexpression of CXCL9 has also shown to reduce tumor progression and metastasis via the inhibition of angiogenesis. Conversely, CXCL9 can act directly on tumor cells expressing the CXCR3 receptor to promote cell migration and epithelial mesenchymal transition. In this chapter we discuss the anti- and pro-tumoral features of CXCL9 within the tumor microenvironment.