Identification of Blomia tropicalis allergen Blo t 5 by cDNA cloning.
Identification of Blomia tropicalis allergen Blo t 5 by cDNA cloning.
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通过 cDNA 克隆鉴定热带布洛米亚过敏原 Blo t 5。
DOI：
10.1159/000237080
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发表时间：
1995
影响因子：
2.8
通讯作者：
Chapman,MD
中科院分区：
文献类型：
--
作者：
Arruda,LK;Fernandez-Caldas,E;Naspitz,CK;Montealegre,F;Vailes,LD;Chapman,MD
布洛米亚属螨虫，包括热带布洛米亚和库拉吉尼布洛米亚，是世界热带和亚热带地区哮喘患者IgE抗体反应的重要原因。据记录，香港、巴西、委内瑞拉、哥伦比亚、台湾、印度、西班牙、埃及和其他国家/地区的房屋中都曾接触过热带芽孢杆菌 [1-3]，在美国，佛罗里达州坦帕、路易斯安那州新奥尔良、田纳西州孟菲斯、德克萨斯州加尔维斯顿、德尔雷比奇和加利福尼亚州圣地亚哥的房屋中已发现大量热带芽孢杆菌。[4]，人们对 Blomia 和 Blomia 之间的抗原交叉反应越来越感兴趣。 Dermatophagoides spp.，因为在这种环境中接触这两种螨虫非常常见。布洛米亚属根据血清学分析和皮肤测试的结果判断，Blomia 是多种过敏原的来源，其中大多数是物种特异性的[3-6]，但目前尚未有纯化的 Blomia 过敏原的报道。我们使用分子克隆技术来进一步鉴定、表征和测序热带芽胞杆菌过敏原。重组过敏原的表达将有助于研究热带拟杆菌的免疫反应，并开发评估接触这种螨虫的风险水平的方法。
Mites of the genus Blomia, including Blomia tropicalis and Blomia kulagini, are an important cause of IgE antibody responses among asthmatic patients in tropical and subtrop ical areas of the world. Exposure to B. tropicalis has been documented in houses from Hong Kong, Brazil, Venezuela, Colombia, Taiwan, India, Spain, Egypt and other countries [1-3], In the United States, B. tropicalis has been identified in significant numbers in homes from Tampa Fla., New Or leans, La., Memphis, Tenn., Galveston, Tex., Delray Beach and San Diego, Calif.[4], There has been increasing interest in the antigenic cross-reactivity between Blomia and Dermatophagoides spp., since exposure to both mite species is very common in such environments. Blomia spp. arc the source of multiple allergens, the majority of which arc spe cies specific, as judged by results of serologic analysis and skin testing [3 6], However, at present no purified Blomia allergens have been reported. We have used molecular clon ing techniques to further identify, characterize and sequence B. tropicalis allergens. Expression of the recombinant al lergens will allow studies on the immune responses to B. tropicalis, and development of methods for assessing risk levels of exposure to this mite.
对热带布洛米亚的过敏：皮试和交叉反应研究。
DOI：
10.1016/0091-6749(94)90200-3
发表时间：
1994
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
B. E. Stanaland;Enrique Fernández;Carlos M. Jacinto;Walter L. Trudeau;R. Lockey
通讯作者：
R. Lockey
瑞典和巴西对库拉吉尼布洛米亚 (Blomia kulagini) 和屋尘螨 (Dermatophagoides pteronyssinus) 的免疫反应。
DOI：
10.1159/000235113
发表时间：
1990
期刊：
International archives of allergy and applied immunology
影响因子：
--
作者：
M. van Hage;L. Machado;M. Barros;S. Johansson
通讯作者：
S. Johansson