Risk for lung cancer in workers exposed to benzidine and/or beta-naphthylamine: a protocol for systematic review and meta-analysis.
Risk for lung cancer in workers exposed to benzidine and/or beta-naphthylamine: a protocol for systematic review and meta-analysis.
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DOI：
10.1186/2046-4053-3-112
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发表时间：
2014-10-03
影响因子：
3.7
通讯作者：
Kurumatani N
中科院分区：
文献类型：
--
作者：
Tomioka K;Saeki K;Obayashi K;Tanaka Y;Kurumatani N
接触联苯胺（BZ）和/或-萘胺（BNA）的工人患肺癌的风险已在许多流行病学研究中进行了调查，但个别流行病学研究通常缺乏检查接触BZ/BNA与肺癌之间关系的能力。联苯胺是众所周知的膀胱癌。我们进行了一项系统回顾和荟萃分析，以确定职业暴露于BZ/BNA的工人患肺癌的风险。研究将通过MEDLINE、EMBASE、CDSR和CINAHL检索以及文章/相关综述的参考文献列表来确定。符合条件的研究将是报告职业BZ/BNA暴露和目标结果（肺癌死亡/发病率）的队列研究和病例对照研究。meta分析方法将用于合并回顾性和前瞻性队列研究的标准化死亡率（SMRs）和/或标准化发病率（SIRs）以及病例对照研究的优势比（ORs）。两名审稿人将独立筛选文章，提取数据，并使用标准化表格和为每个研究设计量身定制的已发表质量评估工具评估科学质量。使用随机效应模型获得总体汇总风险估计值及其相应的95%置信区间（ci）。本系统评价和荟萃分析将遵循流行病学观察性研究荟萃分析（MOOSE）指南进行，结果将根据系统评价和荟萃分析首选报告项目（PRISMA）声明进行报告。本文将对职业BZ/BNA暴露与肺癌之间的关系进行综述。研究结果将有助于确定BZ/BNA是否会导致肺癌，并可能表明接触BZ/BNA的工人是否需要采取除膀胱癌外的非泌尿系统癌症的预防措施。普洛斯彼罗CRD42014010250
Risk for lung cancer in workers exposed to benzidine (BZ) and/or beta-naphthylamine (BNA), which are well-known bladder carcinogens, has been examined in many epidemiological studies, but individual epidemiological studies generally lack the power to examine the association between BZ/BNA exposure and lung cancer. We conduct a systematic review and meta-analysis to determine the risk for lung cancer among workers exposed to BZ/BNA occupationally. Studies will be identified by a MEDLINE, EMBASE, CDSR, and CINAHL search and by the reference lists of articles/relevant reviews. Eligible studies will be cohort and case-control studies that report occupational BZ/BNA exposure and the outcome of interest (lung cancer death/incidence). The method of meta-analysis will be used to combine standardized mortality ratios (SMRs) and/or standardized incidence ratios (SIRs) from retrospective and prospective cohort studies and odds ratios (ORs) from case-control studies. Two reviewers will independently screen articles, extract data, and assess scientific quality using standardized forms and published quality assessment tools tailored for each study design. Overall pooled risk estimates and their corresponding 95% confidence intervals (CIs) will be obtained using random effects model. This systematic review and meta-analysis will be conducted following the Meta-analysis of Observational Studies in Epidemiology (MOOSE) guidelines, and results will be reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. This review will identify and synthesize studies of the association between occupational BZ/BNA exposure and lung cancer. The findings will help to identify whether BZ/BNA could cause lung cancer and might indicate whether workers with exposure to BZ/BNA have a need for preventive measures against non-urological cancer besides bladder cancer. PROSPERO CRD42014010250