Annexin A2 in amniotic fluid : Correlation with histological chorioamnionitis, preterm premature rupture of membranes, and subsequent preterm delivery
Annexin A2 in amniotic fluid : Correlation with histological chorioamnionitis, preterm premature rupture of membranes, and subsequent preterm delivery
复制标题
羊水中的膜联蛋白 A2：与组织学绒毛膜羊膜炎、早产胎膜早破和随后的早产的相关性
DOI：
10.1111/j.1447-0756.2011.01651.x
复制
发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Yanagihara I.
中科院分区：
文献类型：
--
作者：
Namba F;Ina S.;Kitajima H.;Yoshio H.;Miura K;Saito S.;Yanagihara I.
目的：本研究的目的是确定羊水中膜联蛋白A2（一种在羊膜中丰富并调节纤维蛋白稳态的磷脂结合蛋白）的水平是否与组织学绒毛膜炎、早产胎膜早破和随后的早产有关。材料和方法：从55名妊娠32周前早产和/或早产胎膜早破的孕妇中获得羊水 ，并用夹心酶联免疫吸附测定法测量羊水中膜联蛋白A2的水平。结果：组织学绒毛膜炎患者的羊水膜联蛋白A2水平高于其他患者（P= 0.053），而未足月胎膜早破患者羊水中膜联蛋白A2的水平显著高于未足月胎膜早破患者。剩余（P= 0.002）。羊水中膜联蛋白A2水平是一个公平的测试（受试者-操作者特征曲线下的面积= 0.679），羊水中膜联蛋白A2> 878.2 ng/mL预测羊水采样后2周内分娩的敏感性为68.8%，特异性为65.2%，阳性预测值为73.3%，阴性预测值为60.0%。 此外，联合使用羊水中膜联蛋白A2的临界值878.2 ng/mL和白细胞介素-8的临界值13.3 ng/mL提高了特异性（91.3%）和阳性预测值（89.5%）。结论：我们确定了羊水中膜联蛋白A2的水平，特别是结合羊水中白细胞介素-8的水平，作为早产的一种新的预测标志物。
Aim:The aim of this study was to determine whether amniotic fluid levels of annexin A2, a phospholipid‐binding protein that is abundant in amnion and regulates fibrin homeostasis, are associated with histological chorioamnionitis, preterm premature rupture of the membranes, and subsequent preterm delivery.Materials and Methods:Amniotic fluid was obtained from 55 pregnant women with preterm labor and/or preterm premature rupture of the membranes before 32 weeks of gestation, and amniotic fluid levels of annexin A2 were measured with a sandwich enzyme‐linked immunosorbent assay.Results:Amniotic fluid levels of annexin A2 in patients with histological chorioamnionitis was higher than that in the remainder (P= 0.053), whereas amniotic fluid levels of annexin A2 in patients with preterm premature rupture of the membranes was significantly higher than that in the remainder (P= 0.002). Amniotic levels of annexin A2 was a fair test (area under receiver–operator characteristic curve = 0.679), and amniotic fluid levels of annexin A2 > 878.2 ng/mL had a sensitivity of 68.8%, a specificity of 65.2%, a positive predictive value of 73.3%, and a negative predictive value of 60.0% for predicting delivery within 2 weeks after amniotic fluid sampling. Furthermore, the combined use of amniotic fluid cut‐off levels of 878.2 ng/mL for annexin A2 and 13.3 ng/mL for interleukin‐8 improved the specificity (91.3%) and the positive predictive value (89.5%).Conclusions:We identified amniotic fluid levels of annexin A2, especially in combination with amniotic fluid levels of interleukin‐8, as a novel predictive marker for preterm delivery.