Factors predisposing to cavity margin positivity following conservation surgery for breast cancer
Factors predisposing to cavity margin positivity following conservation surgery for breast cancer
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DOI：
10.1016/j.ejso.2004.07.019
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发表时间：
2004-12-01
期刊：
影响因子：
3.8
通讯作者：
Gui, GPH
中科院分区：
文献类型：
--
作者：
Keskek, M;Kothari, M;Gui, GPH
目标。不完全切除导致局部。保乳治疗（BCT）后复发。本研究的目的是检查与腔缘（CM）阳性和返回剧院率相关的因素。保乳手术与整个CM切除是301例303乳腺癌患者的初始程序。其中，258例患者成功地进行了保乳手术，43例患者随后需要乳房切除术的持续参与的边缘。平均和中位随访时间分别为38和42个月（范围6-78）。在303个肿瘤中，有73个发现了阳性CM。通过单变量和多变量分析，大肿瘤大小（p < 0.001）和肿瘤类型（浸润性小叶癌和导管原位癌）（p= 0.043）是CM阳性的显著预测因素。由于CM状态与初始状态有关。边缘（IM）状态，60例IM阳性但CM阴性的接受治疗的癌症避免了在第二次手术中再次切除。完全切除CM应避免需要进一步的再切除手术在大多数患者的初始标本边缘是积极的。(C)2004爱思唯尔有限公司保留所有权利。
Aims. Incomplete excision leads to Local. recurrence following breast conservation therapy (BCT). The aim of this study was to examine factors associated with cavity margin (CM) positivity and return to theatre rates.Methods. Breast conservation surgery with entire CM excision was the initial procedure in 301 patients with 303 breast cancers. Of these, 258 patients were treated successfully with breast conservation surgery and 43 patients subsequently required a mastectomy for persistent involved margins. The mean and median follow-up was 38 and 42 (range 6-78) months, respectively.Results. Positive CMs were found in 73 out of 303 tumours. Large tumour size (p < 0.001) and tumour type (invasive lobular cancer and ductal carcinoma in-situ) (p= 0.043) were significant predictors of CM positivity both by univariate and multivariate analysis. As a result of CM status in relation to initial. margin (IM) status, 60 cancers treated that were IM positive but CM negative avoided return for further excision at a second operative procedure.Conclusion. Complete CM excision should avoid the need for further re-excision surgery in most patients where initial specimen margin was positive. (C) 2004 Elsevier Ltd. All rights reserved.