Deciduoid peritoneal mesothelioma in a dog
Deciduoid peritoneal mesothelioma in a dog
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DOI：
10.1354/vp.43-2-198
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发表时间：
2006-03-01
影响因子：
2.4
通讯作者：
Marcato, PS
中科院分区：
文献类型：
--
作者：
Morini, M;Bettini, G;Marcato, PS
蜕膜样间皮瘤是上皮间皮瘤的一种罕见变体，到目前为止仅在人类病理学中描述，其与妊娠子宫内膜（称为蜕膜）具有显著的细胞形态学相似性。腹膜间皮瘤1例。本文报道了一只10岁雌性犬的子宫内膜异位症。腹膜壁层和肠系膜中的多发性灰白色结节（直径1-5 mm）在组织学上由大的、增殖的、多边形或卵圆形细胞组成，细胞质丰富，嗜酸性，玻璃状。免疫组化结果显示肿瘤细胞共表达角蛋白和波形蛋白，胞浆染色强而弥漫，超微结构分析显示细长的间皮型微绒毛;这些结果证实了肿瘤的间皮起源。
Deciduoid mesothelioma is a rare variant of epithelial mesothelioma, up to now only described in human pathology, which bears remarkable cytomorphologic resemblance to the endometrium of pregnancy, termed decidua. A case of peritoneal mesothelioma. with deciduoid features in a 10-year-old, female dog is reported. Multiple whitish-gray nodules (1-5 mm in diameter) in parietal peritoneum and mesentery were histologically composed of large, proliferating, polygonal or ovoid cells with an abundant eosinophilic, glassy cytoplasm. Immunohistochemical evaluation indicated that the neoplastic cells coexpressed cytokeratin and vimentin with strong and diffuse cytoplasmic staining, and ultrastructural analysis showed long and slender mesothelial-type microvilli; these findings confirmed the mesothelial orgin of the tumor.