IDENTIFICATION OF A MEMBER OF MOUSE SEMAPHORIN FAMILY
IDENTIFICATION OF A MEMBER OF MOUSE SEMAPHORIN FAMILY
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DOI：
10.1016/0014-5793(95)00850-9
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发表时间：
1995-08-21
期刊：
影响因子：
3.5
通讯作者：
IWAHASHI, Y
中科院分区：
文献类型：
--
作者：
INAGAKI, S;FURUYAMA, T;IWAHASHI, Y
蚱蜢信号蛋白 I (Sema I) 及其相关蛋白、厚塌陷蛋白和小鼠 Sema III 通过其驱避作用对轴突引导做出贡献 [5,9,12]，我们从小鼠大脑中鉴定出了信号蛋白基因家族的成员，并将其命名为 M-Sema F，N 端编码一个与 Sema I-III 相似的信号蛋白结构域 [6]，后跟一个假定的免疫球蛋白样结构域，跨膜结构域和富含脯氨酸的细胞内结构域，M-Sema F mRNA 在发育过程中的神经组织中广泛表达，这表明 M-Sema F 是脊椎动物脑信号蛋白家族的跨膜成员，可能在发育中的神经元网络中发挥作用。
Grasshopper semaphorin I (Sema I) and its related proteins, thick collapsin and mouse Sema III contribute to the axon guidance by their repellent actions [5,9,12], We have identified a member of semaphorin gene family from the mouse brain and named it M-Sema F, The N-terminal encodes a semaphorin domain that is similar between Sema I-III [6] followed by a single putative immunoglobulin-like domain, a transmembrane domain, and a proline-rich intracellular domain, M-Sema F mRNA is expressed widely in the nervous tissues during development, These suggest that M-Sema F is a transmembrane member of the semaphorin family of the vertebrate which may function in the developing neuronal network.