Development of a new phantom simulating extracellular space of tumor cell growth and cell edema for diffusion-weighted magnetic resonance imaging.
Development of a new phantom simulating extracellular space of tumor cell growth and cell edema for diffusion-weighted magnetic resonance imaging.
复制标题
开发一种新的模型来模拟肿瘤细胞生长和细胞水肿的细胞外空间，用于扩散加权磁共振成像。
DOI：
10.1007/s10334-019-00823-6
复制
发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Yamasaki Y.
中科院分区：
文献类型：
--
作者：
Mikayama R;Yabuuchi H;Matsumoto R;Kobayashi K;Yamashita Y;Kimura M;Kamitani T;Sagiyama K;Yamasaki Y.
目的为了规范定量评价，需要建立扩散加权成像体模。目的是研制一种模拟不同细胞密度的体模，并评价其重复性。材料和方法用三种不同直径的丙烯酸微粒模拟人体细胞。通过调整10-μm颗粒的体积(分别为5、20、35和50%的体积)来形成四度细胞密度分量。通过调整直径而不改变数量(分别为17%和40%的体积)，还开发了模拟细胞水肿的两级组件。利用Spearman等级相关系数分析了表观扩散系数(ADC)与颗粒密度之间的相关性。计算每组分6个月的ADC变异系数(CV)。结果各组分(5、17、20、35、40、50%体积比)的ADC值分别为1.42、1.30、1.30、1.12、1.09、0.89(× 10−3mm2/S)。ADC值与颗粒比呈负相关(r= − 0.986，p<； 0.05)。ADC的变异系数小于5%。讨论建立了模拟扩散限制与细胞密度和大小相关的体模。
ObjectiveA phantom for diffusion-weighted imaging is required to standardize quantitative evaluation. The objectives were to develop a phantom simulating various cell densities and to evaluate repeatability.Materials and methodsThe acrylic fine particles with three different diameters were used to simulate human cells. Four-degree cell density components were developed by adjusting the volume of 10-μm particles (5, 20, 35, and 50% volume, respectively). Two-degree components to simulate cell edema were also developed by adjusting the diameter without changing number (17% and 40% volume, respectively). Spearman’s rank correlation coefficient was used to find a significant correlation between apparent diffusion coefficient (ADC) and particle density. Coefficient of variation (CV) for ADC was calculated for each component for 6 months. Apvalue < 0.05 represented a statistically significance.ResultsEach component (particle ratio of 5, 17, 20, 35, 40, and 50% volume, respectively) presented ADC values of 1.42, 1.30, 1.30, 1.12, 1.09, and 0.89 (× 10−3mm2/s), respectively. A negative correlation (r= − 0.986,p< 0.05) was observed between ADC values and particle ratio. CV for ADC was less than 5%.DiscussionA phantom simulating the diffusion restriction correlating with cell density and size could be developed.