Extracellular matrix and growth factors in salivary gland development.
Extracellular matrix and growth factors in salivary gland development.
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唾液腺发育中的细胞外基质和生长因子。
DOI：
10.1159/000313707
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
DeVine,Tiffany
中科院分区：
文献类型：
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作者：
Sequeira,SharonJ;Larsen,Melinda;DeVine,Tiffany
间质细胞外基质（ECM）和上皮细胞相关基底膜（BM）在发育中的唾液腺的形态发生和分化中起着关键作用。早期的研究使用离体器官培养和组织重组方法来确定ECM在器官发育中的重要性。转基因小鼠和分子工具的结合促进了我们对ECM蛋白影响SMG发育的机制的理解。最近的工作已经确定了唾液腺疾病（包括Sjögren综合征和唾液腺癌）中ECM、BM和相关蛋白的改变，但这种改变的意义尚不清楚。了解哺乳动物器官发育中控制形态发生和分化的基本机制是了解其发病机制的第一步。ECM和BM在细胞过程中功能的分子表征对于再生医学和组织工程治疗方法的未来发展至关重要。在这里，我们提供了实验的历史概述，定义ECM， ECM受体和相关分子在唾液腺发育中的功能。我们还讨论了ECM相关蛋白酶的功能以及在某种程度上受ECM或相关分子调节的主要生长因子信号成分。最后，我们讨论了唾液腺病理中发生的ECM和BM缺陷，并推测了进一步了解唾液腺ECM功能的未来研究领域。
The interstitial extracellular matrix (ECM) and epithelial-cell associated basement membrane (BM) play critical roles in the morphogenesis and differentiation of developing salivary glands. Early studies used ex vivo organ culture and tissue recombination methods to identify the importance of the ECM in organ development. Incorporation of transgenic mice and molecular tools has facilitated progress in our understanding of the mechanisms by which ECM proteins influence SMG development. Recent work has identified alterations in the ECM, BM, and associated proteins in salivary gland diseases, including Sjögren's syndrome and salivary gland cancers, but the significance of such changes is not known. Understanding the basic mechanisms controlling morphogenesis and differentiation in mammalian organ development is the first step towards understanding pathogenesis. Molecular characterization of the function of the ECM and BM in cellular processes is critical for future development of therapeutic approaches in regenerative medicine and tissue engineering. Here we provide a historical overview of experiments defining the functions of the ECM, ECM receptors, and associated molecules in salivary gland development. We include a discussion of the function of ECM-associated proteases and major growth factor signaling components that are in some way regulated by the ECM or associated molecules. We conclude with a discussion of defects in ECM and BM occurring in salivary gland pathologies and speculation on future areas of research pertaining to further understanding of the function of the ECM in the salivary gland.