Fos-like immunoreactivity in the brain stem following oral quinine stimulation in decerebrate rats
Fos-like immunoreactivity in the brain stem following oral quinine stimulation in decerebrate rats
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DOI：
10.1152/ajpregu.1999.277.2.r384
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发表时间：
1999-08-01
影响因子：
2.8
通讯作者：
Grill, HJ
中科院分区：
文献类型：
--
作者：
Travers, JB;Urbanek, K;Grill, HJ
本研究比较了清醒完整大鼠口服单盐酸奎宁（QHCl）刺激后fos样免疫反应性（FLI）的分布与慢性滤泡上失觉（CD）大鼠的分布。由于对QHCl的行为排斥反应在CD大鼠中很明显，我们假设两组中下脑干FLI的模式应该相似。总的来说，在完整组和CD组中，FLI在脑干的分布非常相似，与未刺激的对照组相比，QHCI刺激增加了孤立束吻侧（味觉）核、臂旁核（PBN）和外侧网状结构（RF）的FLI。然而，CD组与完整组不同，RF中FLI减少的趋势以及标记模式从PEN的外部细分转移。无论口服或不口服，CD大鼠的孤立束尾核的FLI也增加。因此，qhcl诱导的FLI在完整大鼠脑干中的分布既表明了局部感觉运动加工，也表明了前脑结构的影响。
The present study compared the distribution of Fos-like immunoreactivity (FLI) following intraoral stimulation with quinine monohydrochloride (QHCl) in awake intact rats to the pattern obtained in chronic supracollicular decerebrate (CD) rats. Because the behavioral rejection response to QHCl is evident in the CD rat, it was hypothesized that the pattern of FLI in the lower brain stem should be similar in both groups. Overall, the distribution of FLI in the brain stem was quite similar in both intact and CD groups, and QHCI stimulation increased FLI in the rostral (gustatory) nucleus of the solitary tract, the parabrachial nucleus (PBN), and the lateral reticular formation (RF) compared with an unstimulated control group. The CD group differed from the intact group, however, with a trend toward less FLI in the RF and a shift in the pattern of label away from the external subdivision of the PEN. CD rats also had increased FLI in the caudal nucleus of the solitary tract, with or without intraoral infusions. The distribution of QHCl-induced FLI in the brain stem of intact rats thus indicates both local sensorimotor processing as well as the influence of forebrain structures.