Current state of phenolic and terpenoidal dietary factors and natural products as non-coding RNA/microRNA modulators for improved cancer therapy and prevention.
Current state of phenolic and terpenoidal dietary factors and natural products as non-coding RNA/microRNA modulators for improved cancer therapy and prevention.
复制标题
DOI：
10.1016/j.ncrna.2016.07.001
复制
发表时间：
2016-10
影响因子：
5
通讯作者：
Biersack B
中科院分区：
文献类型：
--
作者：
Biersack B
小非编码 RNA 分子 microRNA (miRNA) 对癌细胞的表观遗传调控引起了肿瘤学领域的特别关注。这些 miRNA 在癌细胞的致病特性和癌细胞对抗癌药物的敏感性方面发挥着至关重要的作用。某些 miRNA 负责增强药物活性，而另一些则导致肿瘤耐药性的形成。此外，miRNA 还调节癌细胞的存活和增殖，特别是癌症干细胞样细胞 (CSC)，这些细胞特别具有耐药性，因此在许多情况下会导致肿瘤复发。人们发现了多种小分子化合物以 miRNA 为靶点，而这些 miRNA 已知可调节肿瘤侵袭性和耐药性。这篇综述涵盖了天然存在的小分子（酚类化合物和萜类化合物）对癌症疾病相关 miRNA 的影响。
The epigenetic regulation of cancer cells by small non-coding RNA molecules, the microRNAs (miRNAs), has raised particular interest in the field of oncology. These miRNAs play crucial roles concerning pathogenic properties of cancer cells and the sensitivity of cancer cells towards anticancer drugs. Certain miRNAs are responsible for an enhanced activity of drugs, while others lead to the formation of tumor resistance. In addition, miRNAs regulate survival and proliferation of cancer cells, in particular of cancer stem-like cells (CSCs), that are especially drug-resistant and, thus, cause tumor relapse in many cases. Various small molecule compounds were discovered that target miRNAs that are known to modulate tumor aggressiveness and drug resistance. This review comprises the effects of naturally occurring small molecules (phenolic compounds and terpenoids) on miRNAs involved in cancer diseases.