Structural requirement of tunicamycin V for MraY inhibition
Structural requirement of tunicamycin V for MraY inhibition
复制标题
衣霉素 V 抑制 MraY 的结构要求
DOI：
10.1016/j.bmc.2019.02.035
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Satoshi Ichikawa
中科院分区：
文献类型：
--
作者：
Kazuki Yamamoto;Akira Katsuyama;Satoshi Ichikawa
通过评价一系列截短类似物来阐明构效关系是药物化学中基于具有大而复杂化学结构的天然产物的简单但重要且有效的策略。在这项研究中，一系列截短的类似物的衣霉素V的设计和合成和MraY抑制活性进行了研究，以了解这些部分对MraY抑制的效果。
Elucidating a structure-activity relationship study by evaluating a series of truncated analogues is a simple but important and effective tactic in medicinal chemistry based on natural products with a large and complex chemical structure. In this study, a series of truncated analogues of tunicamycin V were designed and synthesized and their MraY inhibitory activity was investigated in order to gain insight into the effect of these moieties on MraY inhibition.