Why do human B cells secrete granzyme B? Insights into a novel B-cell differentiation pathway.
Why do human B cells secrete granzyme B? Insights into a novel B-cell differentiation pathway.
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DOI：
10.4161/onci.22354
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发表时间：
2012-11-01
期刊：
影响因子：
7.2
通讯作者：
Jahrsdörfer B
中科院分区：
文献类型：
--
作者：
Hagn M;Jahrsdörfer B
B细胞通常被认为是高亲和力抗体的产生者，以保护身体免受微生物的侵害，而细胞毒性被认为是自然杀伤(NK)细胞和细胞毒性T淋巴细胞(CTL)的专有特权。最近的研究表明，白介素21(IL-21)和B细胞受体(BCR)的刺激相结合，能够使B细胞产生和分泌活性形式的细胞毒丝氨酸蛋白酶颗粒酶B(GRB)，这与这一教义相矛盾。尽管B细胞产生GRB不像许多其他分泌GRB的细胞那样伴随着穿孔素的产生，但最近的研究表明，B细胞分泌GRB可能在早期的抗病毒免疫反应、自身免疫反应的调节和癌症免疫监视中发挥重要作用。在这里，我们详细讨论分泌GRB的B细胞如何影响各种免疫过程。更好地了解分泌GRB的B细胞在免疫系统中所起的作用，可能有助于开发和改进针对传染病、自身免疫性疾病和恶性肿瘤的新型免疫治疗方法。
B cells are generally believed to operate as producers of high affinity antibodies to defend the body against microorganisms, whereas cellular cytotoxicity is considered as an exclusive prerogative of natural killer (NK) cells and cytotoxic T lymphocytes (CTLs). In conflict with this dogma, recent studies have demonstrated that the combination of interleukin-21 (IL-21) and B-cell receptor (BCR) stimulation enables B cells to produce and secrete the active form of the cytotoxic serine protease granzyme B (GrB). Although the production of GrB by B cells is not accompanied by that of perforin as in the case of many other GrB-secreting cells, recent findings suggest GrB secretion by B cells may play a significant role in early antiviral immune responses, in the regulation of autoimmune responses, and in cancer immunosurveillance. Here, we discuss in detail how GrB-secreting B cells may influence a variety of immune processes. A better understanding of the role that GrB-secreting B cells are playing in the immune system may allow for the development and improvement of novel immunotherapeutic approaches against infectious, autoimmune and malignant diseases.
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影响因子：
16
作者：
Afonina IS;Tynan GA;Logue SE;Cullen SP;Bots M;Lüthi AU;Reeves EP;McElvaney NG;Medema JP;Lavelle EC;Martin SJ
通讯作者：
Martin SJ
DOI：
10.1164/rccm.200807-1085oc
发表时间：
2009-03-15
影响因子：
24.7
作者：
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通讯作者：
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DOI：
10.1161/01.atv.0000147162.51930.b7
发表时间：
2004-12-01
影响因子：
8.7
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
82.9
作者：
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通讯作者：
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