High resistance against clindamycin, metronidazole and amoxicillin in Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans isolates of periodontal disease
High resistance against clindamycin, metronidazole and amoxicillin in Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans isolates of periodontal disease
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DOI：
10.4317/medoral.15.e947
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发表时间：
2010-11-01
影响因子：
2.2
通讯作者：
Guzman, Isabel C.
中科院分区：
文献类型：
--
作者：
Ardila, Carlos M.;Lopez, Mayra A.;Guzman, Isabel C.
目的：为了测试两种牙周致病菌的抗菌药物的敏感性，一个面板的五个口服抗生素在牙周diseases.Study设计：共69株Aggregatibacter放线菌伴和牙龈卟啉单胞菌进行了处理，使用文化和生化试验。选择A.结果：药敏试验结果显示，对克林霉素、甲硝唑、阿莫西林、阿莫西林/克拉维酸、氟喹诺酮类抗生素的敏感率为100%，对放线菌和牙龈卟啉单胞菌的敏感率为100%。结论：伴放线菌和牙龈卟啉单胞菌对其他抗生素的耐药程度较低，但对其他抗生素的耐药程度较低。放线菌和牙龈卟啉单胞菌感染的患者。这表明，抗生素敏感性测试是必要的，以确定抗菌药物的疗效。抗生素的临床研究应考虑这些差异。
Objectives: To test the antimicrobial sensitivity of two periodontal pathogens to a panel of five orally administrable antibiotics in periodontal disease.Study design: A total of 69 isolates of Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis were processed using culture and biochemical tests. Selected colonies of A. actinomycetemcomitans and P. gingivalis were used to evaluate the antibacterial activity of clindamycin, metronidazole, amoxicillin, moxifloxacin and amoxicillin/clavulanic acid.Results: Susceptibility testing revealed a sensitivity of 100% of A. actinomycetemcomitans and P. gingivalis to moxifloxacin and amoxicillin/clavulanic acid but moderate susceptibilities were found for the rest of antibiotics agents evaluated.Conclusions: The widespread use of antibiotics is reflected in the level of resistance of A. actinomycetemcomitans and P. gingivalis in patients with periodontal infections. This suggests that antibiotic susceptibility testing is necessary to determine efficacy of antimicrobial agents. Clinical studies with antibiotics should take these differences into account.