Strongyloides ratti infections in congenitally hypothymic (nude) mice.
Strongyloides ratti infections in congenitally hypothymic (nude) mice.
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先天性低胸（裸鼠）小鼠的鼠类圆线虫感染。
DOI：
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发表时间：
1982
期刊：
影响因子：
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通讯作者：
D. Grove
中科院分区：
文献类型：
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作者：
H. Dawkins;G. Mitchell;D. Grove
观察了先天性胸腺功能低下的CBA/H、C57BL/6和BALB/c裸鼠感染Ratti类圆线虫的过程。与正常小鼠相比，裸鼠的感染强度和粪便幼虫排泄持续时间均增加。成虫在裸鼠的小肠内存活至少6周。与经皮感染相比，皮下注射后这些小鼠的蠕虫负担更大。胸腺功能低下的小鼠没有对再次感染产生抵抗力。结论：初次感染时的自发驱虫和对攻击感染的抵抗都是T细胞依赖的事件。未见自身感染。
The course of infection with Strongyloides ratti was examined in congenitally hypothymic CBA/H, C57Bl/6 and BALB/c nude mice. The intensity of infection and the duration of faecal larval excretion were both increased in nude mice when compared with intact mice. Adult worms persisted in the small intestine of nude mice for at least 6 weeks. Greater worm burdens were found in such mice after subcutaneous injection as compared with percutaneous infection. Hypothymic mice did not acquire resistance to re-infection. It is concluded that both the spontaneous expulsion of worms in primary infection and resistance to challenge infection are T cell-dependent events. Autoinfection was not seen.