Estrogen receptor positive operable breast cancer: Does menopausal status impact on HER2 and progesterone receptor status?
Estrogen receptor positive operable breast cancer: Does menopausal status impact on HER2 and progesterone receptor status?
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雌激素受体阳性可手术乳腺癌：绝经状态会影响 HER2 和孕激素受体状态吗？
DOI：
10.1016/j.breast.2011.05.009
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发表时间：
2011-12-01
期刊：
影响因子：
3.9
通讯作者：
Hu, Jia
中科院分区：
文献类型：
--
作者：
Wang, Ning;Wang, Bin;Hu, Jia
目的：本研究的目的是确定是否孕激素受体（PgR）和人表皮生长因子受体2（HER 2）的状态不同的绝经状态雌激素受体（ER）阳性乳腺cancer.Patients和方法：我们回顾性分析了588例可手术ER（+）乳腺癌患者的临床病理资料。采用免疫组化法检测ER、HER 2和PgR的表达。在单变量分析中，通过Pearson卡方检验（2）和Fisher精确概率检验评估不同变量之间的关系。使用Logistic回归分析HER 2表达与选定临床病理特征之间的关系。结果：在绝经后ER（+）肿瘤患者中，HER 2与PgR表达呈独立负相关（P = 0.017; OR 3.02; 95%CI 1.22-7.49），在绝经后妇女中，ER（+）/PgR（-）肿瘤表达HER 2的可能性是ER（+）/PgR（+）肿瘤的3.02倍。结论：月经状态对ER（+）乳腺癌患者的HER 2和PgR状态有重要影响。仅在绝经后ER（+）乳腺癌患者中，HER 2与PgR呈独立负相关，而在绝经前乳腺癌患者中则不相关。(C)2011爱思唯尔有限公司保留所有权利。
Purpose: The objective of the present study was to determine whether progesterone receptor (PgR) and human epidermal growth factor receptor 2 (HER2) status differs by menopausal status in estrogen receptor (ER)-positive breast cancers.Patients and methods: We retrospectively analyzed the clinicopathological data of 588 with operable ER(+) breast cancers patients. ER, HER2 and PgR expression in the tumor specimens were examined by immunohistochemistry. The relationship between different variables was assessed by Pearson's chi(2) and Fisher's exact probability tests in univariate analyses. Logistic regression was used for multivariate analyses of relationship between HER2 expression and selected clinicopathological characteristics. Maximum likelihood estimates of the odds ratio (OR) were obtained and 95% confidence intervals (Cl) were calculated.Results: In the postmenopausal women with ER(+) tumors, HER2 was independently inversely associated with PgR expression (P = 0.017; OR 3.02; 95% Cl 1.22-7.49), An ER(+)/PgR(-) tumor was 3.02 times more likely to express HER2 than an ER(+)/PgR(+) tumor in the postmenopausal women. However, an ER(+) tumor in the premenopausal patients failed to show an independent relationship between HER2 and PgR.Conclusion: Menopausal status played a very important role in determining HER2 and PgR status in ER(+) breast cancer patients. HER2 was independently inversely associated with PgR only in the postmenopausal women with ER(+) breast cancers but not in the premenopausal ones. (C) 2011 Elsevier Ltd. All rights reserved.