Increased oxytocin concentrations and prosocial feelings in humans after ecstasy (3,4-methylenedioxymethamphetamine) administration
Increased oxytocin concentrations and prosocial feelings in humans after ecstasy (3,4-methylenedioxymethamphetamine) administration
复制标题
DOI：
10.1080/17470910802649470
复制
发表时间：
2009-01-01
影响因子：
2
通讯作者：
Verkes, R. J.
中科院分区：
文献类型：
--
作者：
Dumont, G. J. H.;Sweep, F. C. G. J.;Verkes, R. J.
MDMA（3，4-亚甲二氧基甲基苯丙胺或oecstasyo）是一种娱乐性使用的药物，具有显着的亲社会效应。尽管在科学文献中有大量的关注，但其亲社会效应的机制尚未在人类中阐明。最近，对动物的研究表明，神经肽催产素可能会引起这些影响。在一项双盲、随机、交叉和安慰剂对照研究中，我们在15名健康志愿者中评估了口服100 mg MDMA或安慰剂后的血液催产素和MDMA浓度以及主观亲社会效应。MDMA诱导了血液催产素浓度的大幅增加和主观亲社会感觉的增加。在受试者中，这些感觉的变化与催产素水平的变化显著正相关，这些感觉与催产素之间的相关性明显强于这些感觉与血液MDMA水平之间的相关性。MDMA诱导人体释放催产素，这可能与摇头丸特有的亲社会效应有关。
MDMA (3,4-methylenedioxymethamphetamine or oecstasyo) is a recreationally used drug with remarkable and characteristic prosocial effects. In spite of abundant attention in the scientific literature, the mechanism of its prosocial effects has not been elucidated in humans. Recently, research in animals has suggested that the neuropeptide oxytocin may induce these effects. In a double blind, randomized, crossover, and placebo-controlled study in 15 healthy volunteers we assessed blood oxytocin and MDMA concentrations and subjective prosocial effects after oral administration of 100 mg MDMA or placebo. MDMA induced a robust increase of blood oxytocin concentrations and an increase of subjective prosocial feelings. Within subjects, the variations in these feelings were significantly and positively correlated with variation in oxytocin levels, and the correlations between these feelings and oxytocin were significantly stronger than those between these feelings and blood MDMA levels. MDMA induces oxytocin release in humans, which may be involved in the characteristic prosocial effects of ecstasy.