Effects of sex steroids on bones and muscles: Similarities, parallels, and putative interactions in health and disease.
Effects of sex steroids on bones and muscles: Similarities, parallels, and putative interactions in health and disease.
复制标题
DOI：
10.1016/j.bone.2015.04.015
复制
发表时间：
2015-11
期刊：
影响因子：
4.1
通讯作者：
Manolagas SC
中科院分区：
文献类型：
--
作者：
Carson JA;Manolagas SC
雌激素和雄激素影响骨骼和肌肉的生长和维持，并对它们的两性异形负责。其循环水平的下降会导致两个组织的质量和功能完整性的丧失。在这篇文章中，我们强调了性类固醇在两种组织中作用的分子和细胞机制的相似性；机械力对组织质量和功能的关键作用的共性；骨骼和肌肉中机械力与激素和生长因子信号之间相互作用的新证据；以及目前支持或反对肌肉和骨骼之间相互作用的证据。此外，我们回顾了骨质疏松症和肌肉减少症的发展与年龄增长的相似之处，以及这两种组织的年龄依赖性退化的潜在共同机制。最后，我们讨论了预防和治疗骨质疏松症的几种药物治疗的可用性的显著差异，相比之下，没有肌肉减少症。
Estrogens and androgens influence the growth and maintenance of bones and muscles and are responsible for their sexual dimorphism. A decline in their circulating levels leads to loss of mass and functional integrity in both tissues. In the article, we highlight the similarities of the molecular and cellular mechanisms of action of sex steroids in the two tissues; the commonality of a critical role of mechanical forces on tissue mass and function; emerging evidence for an interplay between mechanical forces and hormonal and growth factor signals in both bones and muscles; as well as the current state of evidence for or against a cross-talk between muscles and bone. In addition, we review evidence for the parallels in the development of osteoporosis and sarcopenia with advancing age and the potential common mechanisms responsible for the age-dependent involution of these two tissues. Lastly, we discuss the striking difference in the availability of several drug therapies for the prevention and treatment of osteoporosis, as compared to none for sarcopenia.