Hypothalamic Integration of Metabolic, Endocrine, and Circadian Signals in Fish: Involvement in the Control of Food Intake.
Hypothalamic Integration of Metabolic, Endocrine, and Circadian Signals in Fish: Involvement in the Control of Food Intake.
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DOI：
10.3389/fnins.2017.00354
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发表时间：
2017
影响因子：
4.3
通讯作者：
Soengas JL
中科院分区：
文献类型：
--
作者：
Delgado MJ;Cerdá-Reverter JM;Soengas JL
鱼类对食物摄入的调节是一个复杂的过程，它通过中枢神经系统（CNS）的几种不同机制进行，下丘脑是主要的调节中心。与哺乳动物一样，一个复杂的下丘脑回路包括两群神经元：一群共同表达神经肽Y （NPY）和agouti相关肽（AgRP），另一群共同表达促鸦片黑素皮质素（POMC）和可卡因和安非他明调节转录物（CART），参与与食物摄入控制相关的信息整合。这些多肽的产生和释放控制着食物的摄入，其产生来自于不同性质的信息的整合，如营养物质和激素水平以及昼夜节律信号。本文综述了这些机制在鱼类中的存在和功能，以及它们与已知哺乳动物模型的差异。
The regulation of food intake in fish is a complex process carried out through several different mechanisms in the central nervous system (CNS) with hypothalamus being the main regulatory center. As in mammals, a complex hypothalamic circuit including two populations of neurons: one co-expressing neuropeptide Y (NPY) and Agouti-related peptide (AgRP) and the second one population co-expressing pro-opiomelanocortin (POMC) and cocaine- and amphetamine-regulated transcript (CART) is involved in the integration of information relating to food intake control. The production and release of these peptides control food intake, and the production results from the integration of information of different nature such as levels of nutrients and hormones as well as circadian signals. The present review summarizes the knowledge and recent findings about the presence and functioning of these mechanisms in fish and their differences vs. the known mammalian model.