LOCALIZATION OF PROTEIN-KINASES BY ANCHORING PROTEINS - A THEME IN SIGNAL-TRANSDUCTION
LOCALIZATION OF PROTEIN-KINASES BY ANCHORING PROTEINS - A THEME IN SIGNAL-TRANSDUCTION
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DOI：
10.1126/science.7716516
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发表时间：
1995-04-14
期刊：
影响因子：
56.9
通讯作者：
MOCHLYROSEN, D
中科院分区：
文献类型：
--
作者：
MOCHLYROSEN, D
信号转导中的一个基本问题是特定蛋白激酶的刺激如何导致整个细胞中特定蛋白底物的磷酸化。最近的研究表明，特定的锚定蛋白位于不同的网站在细胞区室激酶的作用位点。激酶与其锚定蛋白之间相互作用的抑制剂抑制由激酶介导的功能。这些数据表明，这些锚定蛋白的位置提供了一些由每个激酶介导的反应的特异性，并建议激酶和它们的锚定蛋白之间的相互作用的抑制剂可能是有用的治疗剂。
A fundamental question in signal transduction is how stimulation of a specific protein kinase leads to phosphorylation of particular protein substrates throughout the cell. Recent studies indicate that specific anchoring proteins located at various sites in the cell compartmentalize the kinases to their sites of action. Inhibitors of the interactions between kinases and their anchoring proteins inhibit the functions mediated by the kinases. These data indicate that the location of these anchoring proteins provides some of the specificity of the responses mediated by each kinase and suggest that inhibitors of the interaction between the kinases and their anchoring proteins may be useful as therapeutic agents.