DNA PROFILE MATCH PROBABILITY CALCULATION - HOW TO ALLOW FOR POPULATION STRATIFICATION, RELATEDNESS, DATABASE SELECTION AND SINGLE BANDS
DNA PROFILE MATCH PROBABILITY CALCULATION - HOW TO ALLOW FOR POPULATION STRATIFICATION, RELATEDNESS, DATABASE SELECTION AND SINGLE BANDS
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DOI：
10.1016/0379-0738(94)90222-4
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发表时间：
1994-02-01
影响因子：
2.2
通讯作者：
NICHOLS, RA
中科院分区：
文献类型：
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作者：
BALDING, DJ;NICHOLS, RA
在 DNA 谱分析中，由于采样误差、单条带以及位点内部和位点之间的相关性等多种因素而产生不确定性。 其中最重要的因素之一是亲属关系：犯罪嫌疑人和无辜嫌疑人可能通过来自共同祖先的身份而共享一个或多个族群。 忽视这种不确定性对于无辜嫌疑人来说始终是不公平的。 影响通常很小，但在某些情况下可能很重要。 美国国家研究委员会的报告提出了一种复杂的、临时的、过于保守的方法来处理其中一些问题。 我们提出了一种直接解决亲属关系影响的替代方法。 虽然保持保守，但它简单、逻辑连贯并且有效利用数据。
In DNA profile analysis, uncertainty arises due to a number of factors such as sampling error, single bands and correlations within and between loci. One of the most important of these factors is kinship: criminal and innocent suspect may share one or more bands through identity by descent from a common ancestor. Ignoring this uncertainty is consistently unfair to innocent suspects. The effect is usually small, but may be important in some cases. The report of the US National Research Committee proposed a complicated, ad-hoc and overly-conservative method of dealing with some of these problems. We propose an alternative approach which addresses directly the effect of kinship. Whilst remaining conservative, it is simple, logically coherent and makes efficient use of the data.