Differential effects of aging on transport properties of anterior and posterior human sclera
Differential effects of aging on transport properties of anterior and posterior human sclera
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DOI：
10.1016/s0014-4835(03)00053-8
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发表时间：
2003-06-01
影响因子：
3.4
通讯作者：
Bron, AJ
中科院分区：
文献类型：
--
作者：
Boubriak, OA;Urban, JPG;Bron, AJ
本文比较了44对37-91岁人巩膜的传输特性和成分。对于质量范围为0.023-70 kDa的溶质，后巩膜的溶质运输、扩散和分配系数高于前巩膜;后区也更水合。随着溶质分子量的增加，前后巩膜分配系数的差异变得更加明显。分配系数和水化的两个区域随着年龄的增加而下降。软骨素酶ABC消化，去除大部分的糖胺聚糖，增加分配系数的两个区域显着。这些结果表明，对于巩膜厚度相等的区域，忽略血管因素的影响，在所研究的年龄组中，药物递送将更容易通过后巩膜而不是前巩膜实现，并且对于这两个区域，递送的容易性将随着年龄的降低而降低。(C)2003爱思唯尔科技有限公司。保留所有权利。
The transport properties and composition of 44 pairs of human sclera, 37-91 years were compared. Solute transport, diffusion and partition coefficients of posterior sclera for solutes ranging in mass from 0.023-70 kDa were higher than those of anterior sclera; the posterior region was also more hydrated. The differences in partition coefficient between anterior and posterior sclera became more pronounced as solute molecular weight increased. Partition coefficients and hydration of both regions decreased with increasing age. Chondroitinase ABC digestion, which removed the majority of glycosaminoglycans, increased partition coefficients of both regions significantly. These results suggest that for regions of equal scleral thickness, neglecting the influence of vascular factors, drug delivery will be more readily achieved across the posterior sclera than the anterior sclera in the age group studied and that, for both regions, ease of delivery will decrease with decreasing age. (C) 2003 Elsevier Science Ltd. All rights reserved.