Alterations in creatine metabolism observed in experimental autoimmune myocarditis using ex vivo proton magic angle spinning MRS
Alterations in creatine metabolism observed in experimental autoimmune myocarditis using ex vivo proton magic angle spinning MRS
复制标题
DOI：
10.1002/nbm.3415
复制
发表时间：
2015-10
影响因子：
2.9
通讯作者：
Frédéric Muench;J. Retel;S. Jeuthe;D. O h-Ici;B. van Rossum;K. Wassilew;P. Schmerler;T. Kuehne;F. Berger;H. Oschkinat;D. Messroghli
中科院分区：
文献类型：
--
作者：
Frédéric Muench;J. Retel;S. Jeuthe;D. O h-Ici;B. van Rossum;K. Wassilew;P. Schmerler;T. Kuehne;F. Berger;H. Oschkinat;D. Messroghli
实验性自身免疫性心肌炎（EAM）是心肌炎和扩张型心肌病（DCM）的公认模型。代谢改变被认为在DCM和心力衰竭（HF）的发病机制中起重要作用。对代谢的研究可能为心肌炎和心力衰竭的诊断提供新的信息和机制。质子MRS（1H-MRS）尚未用于研究心肌炎和随后的HF中发生的变化。我们的目的是探索肌酸代谢的变化，使用这个模型，并将它们与健康动物的结果进行比较。
Experimental autoimmune myocarditis (EAM) in rodents is an accepted model of myocarditis and dilated cardiomyopathy (DCM). Altered metabolism is thought to play an important role in the pathogenesis of DCM and heart failure (HF). Study of the metabolism may provide new diagnostic information and insights into the mechanisms of myocarditis and HF. Proton MRS (1H‐MRS) has not yet been used to study the changes occurring in myocarditis and subsequent HF. We aimed to explore the changes in creatine metabolism using this model and compare them with the findings in healthy animals.