MYOINOSITOL METABOLISM IN DIABETES-MELLITUS - EFFECT OF INSULIN-TREATMENT
MYOINOSITOL METABOLISM IN DIABETES-MELLITUS - EFFECT OF INSULIN-TREATMENT
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DOI：
10.2337/diabetes.26.3.215
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发表时间：
1977-01-01
期刊：
影响因子：
7.7
通讯作者：
REYNERTSON, R
中科院分区：
文献类型：
--
作者：
CLEMENTS, RS;REYNERTSON, R
研究了10例非糖尿病患者和6例糖尿病患者胰岛素治疗前后肌醇代谢的变化。两组饮食中肌肌醇摄入量和粪便中肌肌醇排泄量相似，但未经治疗的糖尿病患者尿中肌肌醇排泄量增加了10倍，占其饮食中肌肌醇摄入量的很大一部分。胰岛素治疗使尿肌醇排泄恢复正常。尽管肌肌醇排泄量增加，但糖尿病患者在摄入标准饮食或3.0 g肌肌醇负荷后，血浆肌肌醇浓度显著升高。口服肌醇耐量的这种异常也通过胰岛素治疗得到纠正。在未经治疗的糖尿病患者中，快速平衡肌醇池的大小显著降低，并在短暂的胰岛素治疗后恢复正常。未控制的糖尿病患者摄入肌肌醇后，血浆肌肌醇浓度升高，这可能是肌肌醇的胃肠道吸收增强和细胞内转运受损的结合。肌肌醇分布空间减小表明未经治疗的糖尿病患者细胞内肌肌醇运输受损。推测高血糖可能导致人类普遍存在的相对细胞内肌醇缺乏。恢复正常的细胞内肌醇浓度可能有助于预防和治疗与糖尿病相关的某些并发症。
The metabolism of myoinositol was studied in 10 nondiabetic subjects and in 6 patients with diabetes mellitus before and after insulin therapy. While dietary myoinositol intake and fecal myoinositol excretion were similar in both groups, urinary myoinositol excretion was increased 10-fold in the untreated diabetic and accounted for a significant fraction of his dietary myoinositol intake. Insulin treatment restored the urinary myoinositol excretion toward normal. Despite increased myoinositol excretion, plasma myoinositol concentrations were significantly higher in the diabetics following the ingestion of a standard diet or of a 3.0-g myoinositol load. This abnormality in oral myoinositol tolerance was also corrected by insulin treatment. The size of the rapidly equilibrating myoinositol pool was significantly decreased in the untreated diabetic and returned to normal following a brief period on insulin treatment. The elevated plasma myoinositol concentrations observed following myoinositol ingestion in the uncontrolled diabetic presumably represents a combination of enhanced gastrointestinal absorption and impaired intracellular transport of myoinositol. The decreased space of distribution of myoinositol suggests an impairment of intracellular myoinositol transport in the untreated diabetic. The speculation that hyperglycemia may condition a widespread relative intracellular myoinositol deficiency in man was supported. Restoration of normal intracellular myoinositol concentrations might be beneficial in the prevention and treatment of certain complications associated with human diabetes mellitus.