Differential suppression of testosterone and estradiol in hirsute women with the superactive gonadotropin-releasing hormone agonist leuprolide.
Differential suppression of testosterone and estradiol in hirsute women with the superactive gonadotropin-releasing hormone agonist leuprolide.
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使用超活性促性腺激素释放激素激动剂亮丙瑞林对多毛女性的睾酮和雌二醇进行差异性抑制。
DOI：
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发表时间：
1988
影响因子：
5.8
通讯作者：
R. Rittmaster
中科院分区：
文献类型：
--
作者：
R. Rittmaster
为了确定最大限度地抑制卵巢睾酮分泌所需的 GnRH 激动剂亮丙瑞林的剂量，10 名中度至重度多毛女性（5 名特发性多毛症和 5 名多囊卵巢综合征）被逐渐增加亮丙瑞林剂量，从 5 或 10 微克/公斤·天开始。在每个治疗期之前和结束时测量血清睾酮和雌二醇、基础 LH 以及 LH 对 GnRH 的反应，直到雌二醇和睾酮发生最大抑制。然后继续使用亮丙瑞林总共 6 个月以评估其临床疗效。在治疗前和治疗后测定多毛症评分和毛发生长率。所有女性的血清雌二醇和 LH 对 GnRH 的反应均通过使用最低剂量的亮丙瑞林而得到最大程度或接近最大程度的抑制。在达到 15 微克/公斤·天的剂量之前，并非所有女性的基础血清 LH 都得到最大程度的抑制，10 名女性中有 7 名需要 15 微克/公斤·天或更多的剂量才能最大程度地抑制睾酮。研究结束时，5 名女性每天添加 0.5 毫克地塞米松，持续 4 周，将血清睾酮降低至不可检测的水平。 9 名女性的多毛症症状得到改善，5 名女性的多毛症评分下降至少 3 分，8 名女性的毛发生长速度下降。这些数据表明低剂量的亮丙瑞林足以最大限度地抑制血清雌二醇和 LH 对外源 GnRH 的反应。需要更高剂量的亮丙瑞林才能最大限度地抑制血清睾酮和基础 LH 水平。亮丙瑞林（20 微克/公斤·天）有效减少了大多数女性的毛发生长。
To determine the dose of the GnRH agonist leuprolide necessary to maximally suppress ovarian testosterone secretion, 10 moderately to severely hirsute women (5 with idiopathic hirsutism and 5 with polycystic ovarian syndrome) were given gradually increasing leuprolide doses, starting with either 5 or 10 micrograms/kg.day. Serum testosterone and estradiol, basal LH, and the LH response to GnRH were measured before and at the end of each treatment period, until maximal suppression of estradiol and testosterone occurred. Leuprolide was then continued for a total of 6 months to assess its clinical efficacy. Hirsutism scores and hair growth rates were determined before and after therapy. Serum estradiol and the LH response to GnRH were maximally or near-maximally suppressed in all women by the lowest doses of leuprolide used. Basal serum LH was not maximally suppressed in all women until a dose of 15 micrograms/kg.day was reached, and maximal testosterone suppression required 15 micrograms/kg.day or more in 7 of the 10 women. The addition of 0.5 mg dexamethasone daily for 4 weeks at the end of the study in 5 of the women reduced serum testosterone to undetectable levels. Symptomatic improvement in hirsutism occurred in 9 women, hirsutism scores decreased by at least 3 points in 5 women, and hair growth rates decreased in 8 women. These data indicate that low doses of leuprolide were sufficient to maximally suppress serum estradiol and the LH response to exogenous GnRH. Higher leuprolide doses were needed to maximally suppress serum testosterone and the basal LH levels. Leuprolide (20 micrograms/kg.day) effectively reduced hair growth in the majority of these women.
正常和多毛女性的雄甾烷二醇葡萄糖醛酸血浆清除率和生成率。
DOI：
10.1210/jcem-62-1-22
发表时间：
1986
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Greep,N;Hoopes,M;Horton,R
通讯作者：
Horton,R
慢性促性腺激素释放激素激动剂治疗多囊卵巢病的临床和激素影响。
DOI：
10.1210/jcem-65-4-773
发表时间：
1987
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Steingold,K;DeZiegler,D;Cedars,M;Meldrum,DR;Lu,JK;Judd,HL;Chang,RJ
通讯作者：
Chang,RJ