The Wnt/Ca2+ pathway -: a new vertebrate Wnt signaling pathway takes shape
The Wnt/Ca2+ pathway -: a new vertebrate Wnt signaling pathway takes shape
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DOI：
10.1016/s0168-9525(00)02028-x
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发表时间：
2000-07-01
影响因子：
11.4
通讯作者：
Moon, RT
中科院分区：
文献类型：
--
作者：
Kühl, M;Sheldahl, LC;Moon, RT
脊椎动物Wnt家族的成员根据其生物活性被细分为两个功能类别。一些 Wnt 通过稳定细胞质 β-连环蛋白，通过经典 Wnt-1/wingless 途径发出信号。相比之下，其他 Wnt 以 G 蛋白依赖性方式刺激细胞内 Ca2+ 释放并激活两种激酶 CamKII 和 PKC。此外，已鉴定出属于卷曲基因家族的推定 Wnt 受体，在不存在异位 Wnt 配体的情况下优先与两条预期途径偶联，这可能解释了 Wnt 途径的信号传导特异性。由于 Ca2+ 释放是非经典途径中第一个被描述的特征，并且 Ca2+ 可能在 CamKII 和 PKC 的激活中发挥关键作用，因此我们将此 Wnt 途径命名为 Wnt/Ca2+ 途径。
Members of the vertebrate Wnt family have been subdivided into two functional classes according to their biological activities. Some Wnts signal through the canonical Wnt-1/wingless pathway by stabilizing cytoplasmic beta-catenin. By contrast other Wnts stimulate intracellular Ca2+ release and activate two kinases, CamKII and PKC, in a G-protein-dependent manner. Moreover, putative Wnt receptors belonging to the Frizzled gene family have been identified that preferentially couple to the two prospective pathways in the absence of ectopic Wnt ligand and that might account for the signaling specificity of the Wnt pathways. As Ca2+ release was the first described feature of the noncanonical pathway, and as Ca2+ probably plays a key role in the activation of CamKII and PKC, we have named this Wnt pathway the Wnt/Ca2+ pathway.