A gene regulatory program controlling early Xenopus mesendoderm formation: Network conservation and motifs.
A gene regulatory program controlling early Xenopus mesendoderm formation: Network conservation and motifs.
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DOI：
10.1016/j.semcdb.2017.03.003
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发表时间：
2017-06
影响因子：
7.3
通讯作者：
Cho KWY
中科院分区：
文献类型：
--
作者：
Charney RM;Paraiso KD;Blitz IL;Cho KWY
胚层的形成是后生动物胚胎最早的分化过程之一。在三胚层中，形成三个胚层，其中内胚层产生肠管和相关器官（包括肝、胰腺和肺）的上皮衬里。在蛙（非洲爪蟾）中，早期胚层的形成已被深入研究，内胚层特化的过程涉及几十个转录因子的相互作用。在这里，我们回顾这些因素之间的相互作用，总结在转录基因调控网络（GRN）。我们强调监管之间的连接保存爪蟾，斑马鱼，小鼠和人类内胚层谱系。尤其突出的是Nodal信号传导途径和T-box转录因子Vegt和Eomes的保守作用和调节靶点。此外，我们强调了一些网络拓扑结构和图案，并推测它们在发展中可能发挥的作用。
Germ layer formation is among the earliest differentiation events in metazoan embryos. In triploblasts, three germ layers are formed, among which the endoderm gives rise to the epithelial lining of the gut tube and associated organs including the liver, pancreas and lungs. In frogs (Xenopus), where early germ layer formation has been studied intensively, the process of endoderm specification involves the interplay of dozens of transcription factors. Here, we review the interactions between these factors, summarized in a transcriptional gene regulatory network (GRN). We highlight regulatory connections conserved between Xenopus, zebrafish, mouse, and human endodermal lineages. Especially prominent is the conserved role and regulatory targets of the Nodal signaling pathway and the T-box transcription factors, Vegt and Eomes. Additionally, we highlight some network topologies and motifs, and speculate on their possible roles in development.