The cycloaddition strategy for the synthesis of natural products containing carbocyclic seven-membered rings
The cycloaddition strategy for the synthesis of natural products containing carbocyclic seven-membered rings
复制标题
DOI：
10.1002/chem.200501083
复制
发表时间：
2006-04-14
影响因子：
4.3
通讯作者：
Wrightthl, DL
中科院分区：
文献类型：
--
作者：
Battiste, MA;Pelphrey, PM;Wrightthl, DL
高度取代的碳环七元环常见于天然产物中，其合成对合成化学家来说是一个重大挑战。这些系统的直接分子内环化通常被证明是困难的，这一事实促进了基于收敛分子间环加成策略的各种策略的发展。这篇概念文章讨论了用于获取这些类型结构的主要环加成方法，并主要关注天然产物合成中使用的示例。
Highly substituted carbocyclic seven-membered rings are frequently found in natural products and their synthesis represents a significant challenge to the synthetic chemist. Direct intramolecular cyclization of these systems often proves difficult and this fact has catalyzed the development of a variety of strategies based on a convergent intermolecular cycloaddition strategy. This concept article discusses the major cycloaddition approaches utilized to access these types of structures and primarily focuses on examples employed in the synthesis of natural products.