A population-based observational study of dental caries among survivors of childhood cancer
A population-based observational study of dental caries among survivors of childhood cancer
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DOI：
10.1002/pbc.21464
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发表时间：
2008-06-01
影响因子：
3.2
通讯作者：
Poulsen, Sven
中科院分区：
文献类型：
--
作者：
Wogelius, Pia;Dahllof, Goran;Poulsen, Sven
背景少数发表的关于儿童癌症幸存者龋齿的研究规模很小，而且他们的结果相互矛盾。这项研究的目的是调查癌症幸存儿童患龋齿的风险。Procedure.我们纳入了1984年至1988年出生的299，426名7岁，313，461名12岁和301，930名15岁儿童，这些儿童在一项全国性的基于人口的研究中将丹麦癌症登记处的记录与国家口腔健康数据库的记录联系起来。根据龋齿的存在，将牙科检查之前被诊断为癌症的儿童（288名7岁，459名12岁和526名15岁）与无癌症儿童进行比较：无龋齿儿童;有任何龋齿经历的儿童;和有严重龋齿经历的儿童（即，一个或多个光滑牙齿表面的龋齿）。结果在5岁之前被诊断患有癌症的儿童在12岁和15岁时恒牙龋齿患病率没有增加。5 - 6岁诊断为癌症的儿童在12岁时严重龋齿的患病率增加（患病率比（PR）= 1.59（95%CI：1.09-2.31; P = 0.02）），但这种差异在15岁时消失。在5 ~ 6岁时被诊断为癌症并接受放射治疗的儿童中，重度龋齿的PR为1.52（95%CI：0.97-2.37; P=0.07）、2.13（95%CI：0.89-5.10; P=0.09）和0.31（95%CI：0.071.45; P=0.13）。结论儿童时期的癌症和癌症治疗是龋齿的危险因素。
Background. The few published studies on caries among childhood cancer survivors are small and their results are conflicting. The study aim was to examine the risk of dental caries among children who have survived cancer. Procedure. We included 299,426 7-year-old, 313,461 12-year-old, and 301,930 15-year-old children born between 1984 and 1988 in a nationwide population-based study linking records from Danish Cancer Registry with records from the national database on oral health. Children whose dental examinations had been preceded by a cancer diagnosis (288 7-year-old, 459 12-year-old, and 526 15-year-old) were compared with children without cancer according to presence of caries: caries-free children; children with any caries experience; and children with severe caries experience (i.e., caries in one or more smooth tooth surface). Results. Children diagnosed with cancer before the age of 5 years did not have increased caries prevalence in permanent teeth at ages 12; and 15. Children diagnosed with cancer between 5 and 6 years of age had an increased prevalence of severe caries at age 12 years (prevalence ratio (PR) = 1.59 (95% CI: 1.09-2.31; P = 0.02)), but this difference disappeared by age 15. For children diagnosed with cancer at 5 or 6 years of age and who received radiation therapy the PR of severe caries was 1.52 (95% CI: 0.97-2.37; P=0.07), 2.13 (95% CI: 0.89-5.10; P=0.09), and 0.31 (95% CI: 0.071.45; P=0.13) at ages seven, 12 and 15 years respectively. Conclusion. Cancer and cancer treatment during childhood are risk factors for caries.