Nanoparticles in β-tricalcium phosphate substrate enhance modulation of and structure and composition of an octacalcium phosphate grown layer
Nanoparticles in β-tricalcium phosphate substrate enhance modulation of and structure and composition of an octacalcium phosphate grown layer
复制标题
β-磷酸三钙基质中的纳米粒子增强了磷酸八钙生长层的结构和组成的调节
DOI：
10.1039/c7ce01563a
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发表时间：
2017
期刊：
影响因子：
3.1
通讯作者：
Mayumi Iijima
中科院分区：
文献类型：
--
作者：
Kazuo Onuma;Mayumi Iijima
将 c 轴取向的磷酸八钙 (Ca8(HPO4)2(PO4)4·5H2O; OCP) 层在浸入磷酸钙溶液（弱酸性至碱性 pH 值；体温）的 β-磷酸三钙 (β-Ca3(PO4)2; β-TCP) 颗粒的压缩成型基材上制备。透射电子显微镜显示，当基质由微晶组成时，OCP 直接在 β-TCP 上生长。在初始生长阶段，OCP 的结构和化学成分（钙/磷酸盐摩尔比）受到 (100) 面 d(100) 晶面间距收缩的调节。虽然 d(100) 随着生长很快恢复到理想值，但化学成分的调节需要很长一段时间才能恢复。 d(100) 收缩归因于 OCP 结构中缺少 HPO4-H2O 层。当基材由纳米颗粒组成时，羟基磷灰石（Ca10(PO4)6(OH)2；HAP）晶体首先在基材上生长，然后OCP晶体在其上过度生长。 OCP的结构和化学成分在初始阶段表现出与微晶基底相似的调节。在后期观察到d(100)的轻微伸长，并且成分调节的恢复需要比微晶基底更长的时间。 β-TCP 基质中的纳米颗粒显示出它们增强了 OCP 结构和化学成分调节的证据。
A c-axis oriented octacalcium phosphate (Ca8(HPO4)2(PO4)4·5H2O; OCP) layer was fabricated on a compression-molded substrate of β-tricalcium phosphate (β-Ca3(PO4)2; β-TCP) particles immersed in a calcium phosphate solution (weakly acidic to basic pH; body temperature). Transmission electron microscopy showed that OCP grew directly on β-TCP when the substrate consisted of microcrystals. The structure and chemical composition (calcium/phosphate molar ratio) of OCP were modulated by interplanar distance shrinkage of the (100) plane, d(100), during the initial growth stages. While the d(100) soon recovered to an ideal value with growth, the modulation of the chemical composition recovered over a long period. The d(100) shrinkage is attributed to the lack of an HPO4–H2O layer in the OCP structure. When the substrate consisted of nanoparticles, hydroxyapatite (Ca10(PO4)6(OH)2; HAP) crystals first grew on the substrate, and then OCP crystals overgrew them. The structure and chemical composition of OCP showed modulation similar to that of the microcrystal substrate during the initial stages. Slight elongation of d(100) was inversely observed during the later stages, and recovery of composition modulation took longer than that with the microcrystal substrate. Nanoparticles in the β-TCP substrate showed evidence that they enhance the structure and chemical composition modulations in OCP.