Overexpression of cyclooxygenase-2 in human prostate carcinoma and prostatic intraepithelial neoplasia-association with increased expression of polo-like kinase-I
Overexpression of cyclooxygenase-2 in human prostate carcinoma and prostatic intraepithelial neoplasia-association with increased expression of polo-like kinase-I
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DOI：
10.1002/pros.20467
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发表时间：
2007-03-01
期刊：
影响因子：
2.8
通讯作者：
Kristiansen, Glen
中科院分区：
文献类型：
--
作者：
Denkert, Carsten;Thoma, Andrea;Kristiansen, Glen
背景。环氧合酶 (COX) 以及 Polo 样激酶 (PLK) 参与增殖和细胞周期调节，并已被建议用于前列腺癌的预防和治疗方法。在本研究中，我们研究了 COX-2 在侵袭性前列腺癌、前列腺上皮内瘤变 (PIN)、萎缩性腺体和正常前列腺中的表达和预后影响，并研究了 COX-2 和 PLK-1 之间的关联。 结果。我们观察到 72.1% 的 PIN 和 44.7% 的前列腺癌中 COX-2 呈阳性，与良性前列腺组织相比，前列腺癌和 PIN 中 COX-2 过表达（P < 0.0005）。此外，我们观察到 PLK-1 和 COX-2 的表达之间存在很强的相关性 (P < 0.0005)。 结论。据我们所知，这是首次报道恶性肿瘤中 COX-2 和 PLK-1 之间的相关性。 COX-2 和 PLK-1 可能是前列腺癌新分子疗法的有趣靶点。
BACKGROUND. Cyclooxygenases (COX) as well as Polo-like kinases (PLK) are involved in proliferation and cell cycle regulation and have been suggested for preventive and therapeutic approaches in prostate carcinoma.METHODS. In this study, we studied expression and prognostic impact of COX-2 in invasive prostate carcinoma, prostatic intraepithelial neoplasia (PIN), atrophic glands, and normal prostatic glands, and investigated the association between COX-2 and PLK-1.RESULTS. We observed a positivity for COX-2 in 72.1% of PIN and in 44.7% of prostate carcinomas with an overexpression of COX-2 in prostate cancer and PIN compared to benign prostatic tissue (P < 0.0005). Furthermore, we observed a strong correlation between expression of PLK-1 and COX-2 (P < 0.0005).CONCLUSIONS. To our knowledge, this is the first report of a correlation between COX-2 and PLK-1 in a malignant tumor. COX-2 and PLK-1 may be interesting targets for new molecular therapies in prostate cancer.