Is Reaction Time Slowing an Early Sign of Alzheimer's Disease? A Meta-Analysis
Is Reaction Time Slowing an Early Sign of Alzheimer's Disease? A Meta-Analysis
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DOI：
10.1159/000500348
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发表时间：
2019-10-01
影响因子：
2.4
通讯作者：
Godefroy, Olivier
中科院分区：
文献类型：
--
作者：
Andriuta, Daniela;Diouf, Momar;Godefroy, Olivier
背景：尽管简单反应时(SRT)减慢与阿尔茨海默病(AD)的痴呆有关，但在轻度认知障碍(MCI)患者中是否存在SRT减慢仍存在争议。目的：本研究的目的是对有关MCI患者SRT减慢的文献资料进行系统回顾和荟萃分析。方法：纳入有关MCI患者的SRT、年龄和教育水平数据的出版物。在计算了每个研究的对数SRT及其方差后，我们通过进行随机效应(约束最大似然估计)Meta分析来考虑研究间的异质性。结果：7项研究共纳入327名MCI患者和468名健康对照(HCS)。MCI患者的平均年龄为68.2岁，HCS患者的平均年龄为72.3岁。MCI组和HC组的加权平均简明智力状态检查得分分别为26.4和28.4。MCI组的平均SRT显著(p=0.0217)长于HC组(增加11%)。结论：Meta分析表明，MCI患者的SRT较长。需要进一步的研究来确定SRT减慢的机制、其解剖学相关性以及诊断前驱AD的阈值。
Background: Although simple reaction time (SRT) slowing is associated with dementia in Alzheimer's disease (AD), its presence in individuals with mild cognitive impairment (MCI) is subject to debate. Objective: The aim of this study was to perform a systematic review and meta-analysis of the literature data on SRT slowing in MCI. Methods: Publications with data on SRT, age, and educational level in participants with MCI were included. After calculating the log SRT and its variance for each study, we took interstudy heterogeneity into account by conducting a random effects (restricted maximum likelihood estimation) meta-analysis. Results: The 7 selected studies featured a total of 327 participants with MCI and 468 healthy controls (HCs). The mean age was 68.2 years for participants with MCI and 72.3 years for HCs. The weighted mean Mini-Mental State Examination score was 26.4 in the MCI group, and 28.4 in the HC group. The mean SRT was significantly (p = 0.0217) longer in the MCI group (by 11%) than in the HC group. Conclusion: This meta-analysis showed that SRTs are longer in individuals with MCI. Further studies are needed to determine the mechanism of SRT slowing, its anatomical correlates, and a threshold value for diagnosing prodromal AD.