Noninvasive photoacoustic imaging of the developing vasculature during early tumor growth
Noninvasive photoacoustic imaging of the developing vasculature during early tumor growth
复制标题
早期肿瘤生长期间正在发育的脉管系统的无创光声成像
DOI：
10.1088/0031-9155/53/15/013
复制
发表时间：
2008-08-07
影响因子：
3.5
通讯作者：
Xiang, Liangzhong
中科院分区：
文献类型：
--
作者：
Lao, Yeqi;Xing, Da;Xiang, Liangzhong
在这项研究中，我们在小鼠体内皮下接种乳腺癌肿瘤细胞后 20 天，使用光声成像监测血管系统在早期肿瘤生长中的进展。采用532 nm激光脉冲作为照射源，通过水听器正交模式接收光声信号获得光声图像。肿瘤区域脉管系统的形态特征在光声图像中清晰可见，并且可以识别结构的变化以及密度的增加。此外，肿瘤区域脉管系统的平均光声信号强度与血液总血红蛋白浓度高度相关，在肿瘤生长早期增强。这些结果表明通过光声成像检测早期肿瘤和监测抗血管生成治疗进展的可行性。
In this study, we monitor the progress of vasculature in early tumor growth using photoacoustic imaging over a 20 day period after subcutaneous inoculation of breast cancer tumor cells in a mouse. With 532 nm laser pulses employed as an irradiation source, the photoacoustic images were obtained through the photoacoustic signals received by a hydrophone in orthogonal mode. The morphological characteristics of vasculature in tumor region are clearly resolved in the photoacoustic images, and the change in structure as well as the increase in density can be identified. Moreover, the average photoacoustic signal strength of vasculature in tumor region, which is highly correlated with the total hemoglobin concentration of blood, is enhanced during early tumor growth. These results indicate the feasibility of detecting early stage tumor and monitoring the progress of anti-angiogenic therapy by photoacoustic imaging.