Enzyme Mechanism from Isotope Effects
Enzyme Mechanism from Isotope Effects
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发表时间：
1991-09
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通讯作者：
P. Cook
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作者：
P. Cook
同位素效应的理论基础初级和次级氢同位素效应的理论基础。重原子同位素效应的起源和解释。溶剂同位素效应的理论基础和机理应用。酶反应中的氢瞬变和耦合运动。酶催化反应中的同位素效应同位素对酶反应瞬态动力学的影响。酶催化反应中的本征同位素效应。同位素效应中酶的动力学和调节机制。酶催化反应中同位素效应的pH依赖性。酶催化反应中的多同位素效应。同位素效应的测定方法（有限应用）。竞争和非竞争动力学同位素效应的测定方法。用同位素比质谱仪研究重原子同位素效应。使用稳定同位素远程标记技术测定酶催化反应中的同位素效应。用吸收光谱法测定重水中氘的克原子百分比。特定酶反应中的同位素效应。同位素对酶催化氧化还原反应的影响。水解酶反应的动力学同位素效应。同位素对酶催化b-消除反应的影响。酶催化基团转移反应中的同位素效应。磷酸丙糖异构酶和脯氨酸消旋酶：反应能量学的启示。胸苷酸合成酶催化反应中的同位素效应。
THEORETICAL BASIS FOR ISOTOPE EFFECTS. Theoretical Basis for Primary and Secondary Hydrogen Isotope Effects. Origins and Interpretations of Heavy-Atom Isotope Effects. Theoretical Basis and Mechanistic Utility of Solvent Isotope Effects. Hydrogen Tunneling and Coupled Motion in Enzyme Reactions. ISOTOPE EFFECTS IN ENZYME-CATALYZED REACTIONS. Isotope Effects on the Transient Kinetics of Enzyme Reactions. Instrinsic Isotope Effects in Enzyme-Catalyzed Reactions. Kinetic and Regulatory Mechanisms of Enzymes from Isotope Effects. pH Dependence of Isotope Effects in Enzyme-Catalyzed Reactions. Multiple Isotope Effects in Enzyme-Catalyzed Reactions. METHODS FOR THE DETERMINATION OF ISOTOPE EFFECTS (LIMITED APPLICATIONS). Methods for the Determination of Competitive and Noncompetitive Kinetic Isotope Effects. Heavy Atom Isotope Effects Using the Isotope Ratio Mass Spectrometer. Use of the Stable Isotope Remote Label Technique to Determine Isotope Effects in Enzyme-Catalyzed Reactions. Measuring the Gram-Atom Percent of Deuterium in Heavy Water by Absorption Spectroscopy. ISOTOPE EFFECTS IN SPECIFIC ENZYMIC REACTIONS. Isotope Effects on Enzyme-Catalyzed Redox Reactions. Kinetic Isotope Effects for Hydrolase Reactions. Isotope Effects on Enzyme Catalyzed b-Eliminations. Isotope Effects in Enzyme-Catalyzed Group Transfer Reactions. Triosephosphate Isomerase and Proline Racemase: Revelation of Reaction Energetics. Isotope Effects in Reactions Catalyzed by Thymidylate Synthase.