Influence of hyperproteinemia on reproductive development in an invertebrate model
Influence of hyperproteinemia on reproductive development in an invertebrate model
复制标题
DOI：
10.7150/ijbs.33310
复制
发表时间：
2019-08
影响因子：
9.2
通讯作者：
Yongfeng Wang;Xuedong Chen;Guang Wang;Qiuying Li;Xinyin Liang;Y. Sima;Shiqing Xu
中科院分区：
文献类型：
--
作者：
Yongfeng Wang;Xuedong Chen;Guang Wang;Qiuying Li;Xinyin Liang;Y. Sima;Shiqing Xu
高蛋白血症是一种严重的代谢性疾病，其特征是血浆蛋白浓度（PPC）异常升高。然而，目前尚无可靠的PPC动物模型，因此高蛋白血症的病理机制仍不清楚。在这项研究中，我们评估了高蛋白血症对无脊椎动物家蚕模型生殖发育的影响，该模型具有可控的PPC且无原发疾病影响。高PPC抑制代谢组织脂肪体中雌性卵巢发育所必需的卵黄原蛋白和30 K蛋白的合成，并抑制它们通过血淋巴转运到卵巢。高PPC还诱导睾丸和卵巢细胞程序性死亡，生殖细胞发育减慢，生殖系数显著降低。此外，在该家蚕模型中，高PPC诱导的生殖毒性的强度和机制在性别之间存在差异。
Hyperproteinemia is a severe metabolic disease characterized by abnormally elevated plasma protein concentrations (PPC). However, there is currently no reliable animal model for PPC, and the pathological mechanism of hyperproteinemia thus remains unclear. In this study, we evaluated the effects of hyperproteinemia on reproductive development in an invertebrate silkworm model with a controllable PPC and no primary disease effects. High PPC inhibited the synthesis of vitellogenin and 30K protein essential for female ovarian development in the fat body of metabolic tissues, and inhibited their transport through the hemolymph to the ovary. High PPC also induced programmed cell death in testis and ovary cells, slowed the development of germ cells, and significantly reduced the reproductive coefficient. Furthermore, the intensities and mechanisms of high-PPC-induced reproductive toxicity differed between sexes in this silkworm model.