A longitudinal study of gastric emptying and upper gastro intestinal symptoms in patients with diabetes mellitus
A longitudinal study of gastric emptying and upper gastro intestinal symptoms in patients with diabetes mellitus
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DOI：
10.1016/s0002-9343(02)01228-7
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发表时间：
2002-10-15
影响因子：
5.9
通讯作者：
Horowitz, M
中科院分区：
文献类型：
--
作者：
Jones, KL;Russo, A;Horowitz, M
目得：评价糖尿病患者胃排空和上消化道症状的自然史，主题和方法：我们招募了20例糖尿病患者（6名男性，14名女性）（16例1型糖尿病，4例2型糖尿病）。每个人都有测量胃排空固体（100克碎牛肉）和液体（150 mL 10%葡萄糖）餐，使用血糖描记术，血糖控制（糖化血红蛋白[HbA（1c）]和平均血糖水平）、上消化道症状和自主神经功能在基线和平均（+/- SD）12.3 +/- 3.1年的随访后。固体成分的平均胃排空无差异（基线时100分钟的保留率：56% +/- 19% vs.随访：51% +/-21%，P = 0.23）或液体成分（基线时50%排空时间：33 +/- 11分钟vs.随访：31 +/- 12分钟，P = 0.71）。随访时平均血糖（17.0 +/- 5.6 mmol/L vs. 13.8 +/- 4.9 mmol/L，P = 0.007）和HbA（1c）（8.4% +/- 2.3% vs. 7.6% +/-1.3%，P = 0.03）水平较低。症状评分无差异（基线：3.9 +/- 2.7 vs.随访：4.2 +/- 4.0，P = 0.78）。有证据表明，自主神经病变7例（35%）在基线和16（80%）在follow-up.Conclusion：在糖尿病患者中，我们没有观察到任何显着的变化，无论是胃排空或上消化道症状在12年期间。
PURPOSE: To evaluate the natural history of gastric emptying and upper gastrointestinal symptoms in patients with diabetes mellitus.SUBJECTS AND METHODS: We enrolled 20 patients (6 men, 14 women) with diabetes mellitus (16 with type 1 diabetes, 4 with type 2 diabetes). Each had measurements of gastric emptying of a solid (100 g of ground beef) and liquid (150 mL of 10% dextrose) meal using scintigraphy, glycemic control (glycosylated hemoglobin [HbA(1c)] and mean blood glucose levels), upper gastrointestinal symptoms, and autonomic nerve function at baseline and after a mean (+/- SD) of 12.3 +/- 3.1 years of follow-up.RESULTS: There were no differences in mean gastric emptying of the solid component (retention at 100 minutes at baseline: 56% +/- 19% vs. follow-up: 51% +/- 21%, P = 0.23) or the liquid component (time for 50% to empty at baseline: 33 +/- 11 minutes vs. follow-up: 31 +/- 12 minutes, P = 0.71) during follow-up. Mean blood glucose (17.0 +/- 5.6 mmol/L vs. 13.8 +/- 4.9 mmol/L, P = 0.007) and HbA(1c) (8.4% +/- 2.3% vs. 7.6% +/- 1.3%, P = 0.03) levels were lower at follow-up. There was no difference in symptom score (baseline: 3.9 +/- 2.7 vs. follow-up: 4.2 +/- 4.0, P = 0.78). There was evidence of autonomic neuropathy in 7 patients (35%) at baseline and 16 (80%) at follow-up.Conclusion: In patients with diabetes mellitus, we did not observe any marked changes in either gastric emptying or upper gastrointestinal symptoms during a 12-year period.