Neurilemomas and salivary gland tumors of the head and neck following childhood irradiation.
Neurilemomas and salivary gland tumors of the head and neck following childhood irradiation.
复制标题
儿童照射后头部和颈部的神经鞘瘤和唾液腺肿瘤。
DOI：
10.1002/1097-0142(19830615)51:12
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发表时间：
1983
期刊：
影响因子：
6.2
通讯作者：
Schneider,AB
中科院分区：
文献类型：
--
作者：
Shore-Freedman,E;Abrahams,C;Recant,W;Schneider,AB
在一项联系和检查 4180 名曾因扁桃体和腺样体肿大而接受过儿童放射治疗的个体的计划中，作者在已发现的 2311 名受试者中发现了 29 例神经鞘瘤、2 例神经纤维瘤和 1 例神经节神经瘤。其中 10 例表现为听神经瘤，21 例表现为颈部肿块病变，1 例位于上后纵隔。由于它们的数量及其严格定位于治疗区域，因此得出结论，它们是由辐射引起的。对这些肿瘤潜伏期的分析表明，它们在辐射暴露后至少持续发生 30 年。在同一组个体中，已确诊54例唾液腺肿瘤，其中良性40例，恶性14例。这些肿瘤在辐射暴露多年后仍继续发生。
In a program to contact and examine 4180 individuals with a history of childhood irradiation treatment for enlarged tonsils and adenoids, the authors have discovered 29 neurilemomas, two neurofibromas, and one ganglioneuroma in the 2311 subjects who have been found. Ten of these presented as acoustic neuromas, 21 presented as cervical mass lesions, and one was found in the superior posterior mediastinum. Because of their numbers and their strict localization to the area of treatment, it was concluded that they were radiation‐induced. Analysis of the latency of these tumors indicates that they continue to occur for at least 30 years after the radiation exposure. In the same group of individuals, there have been 54 confirmed salivary gland tumors, 40 benign and 14 malignant. These tumors are also continuing to occur many years after the radiation exposure.