Effects of Maternal Ω-3 Supplementation on Fatty Acids and on Visual and Cognitive Development
Effects of Maternal Ω-3 Supplementation on Fatty Acids and on Visual and Cognitive Development
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DOI：
10.1097/mpg.0000000000000864
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发表时间：
2015-10-01
影响因子：
2.9
通讯作者：
Lara-Villoslada, Federico
中科院分区：
文献类型：
--
作者：
Hurtado, Jose A.;Iznaola, Carmen;Lara-Villoslada, Federico
目的：探讨富含omega-3长链多不饱和脂肪酸(LC-PUFA)的乳饮料对母亲和新生儿血脂的影响及其对新生儿视力和认知发育的影响。方法：将110例孕妇随机分为两组：对照组(54例)和补充组(鱼油[FO])(56例)。每天服用400毫升富含鱼油的乳饮料(包括类似于400毫克二十碳五烯酸-二十二碳六烯酸[DHA]/天)。在研究期间，母亲的饮食由营养学家监督，以鼓励遵守目前关于FA摄入量的建议。在母亲(登记时、分娩时、2.5个月和4个月时)和新生儿(分娩时和2.5个月时)胎盘和母乳(初乳和1个月、2个月和4个月时)中测定血液脂肪酸谱。记录2.5个月和7.5个月的图形翻转视觉诱发电位(VEP)和12个月的Bayley检验。结果：FO组的血浆、红细胞膜和母乳中DHA的百分比较高。FO组母血和新生儿血中神经酸的比例也较高。在贝利检验中没有观察到差异。两组间VEP差异无统计学意义。然而，补充组的男孩在较低的视角(7.5‘)下观察到较短的潜伏期。结论：孕期和哺乳期补充omega-3 LC-PUFA影响母亲和新生儿的脂肪酸组成和神经酸含量，但对视觉和认知/精神运动发育没有影响。
Objectives: The aim of the present study was to elucidate whether a dairy drink enriched with omega-3 long-chain polyunsaturated fatty acid (LC-PUFA) could have an impact on the lipid profile of the mother and the newborn, and also whether this intervention could affect the newborns' visual and cognitive development.Methods: A total of 110 pregnant women were randomly assigned to one of the following intervention groups: control group (n = 54), taking 400 mL/day of the control dairy drink, and supplemented group (fish oil [FO]) (n = 56), taking 400 mL/day of the fish oil-enriched dairy drink (including similar to 400 mg eicosapentaenoic acid-docosahexaenoic acid [DHA]/day). During the study, the mothers' diets were supervised by a nutritionist to encourage compliance with present recommendations of FA intake. Blood fatty acid profiles were determined in the mother's (at enrollment, at delivery, and at 2.5 and 4 months) and newborn (at delivery and at 2.5 months) placenta and breast milk (colostrum and at 1, 2, and 4 months). Pattern reversal visual evoked potentials (VEPs) (at 2.5 and 7.5 months) and Bayley test (at 12 months) were recorded.Results: DHA percentage was higher in plasma, erythrocyte membranes, and breast milk samples from the FO group. The ratio of nervonic acid was also higher in plasma and erythrocyte lipids of the mother and newborn's blood samples from the FO group. No differences were observed in the Bayley test. No differences were observed in VEPs between both groups. We observed a shorter latency, however, in the lower visual angle (7.5') in the boys of the supplemented group.Conclusions: Omega-3 LC-PUFA dietary supplement during pregnancy and lactation influenced the mother and newborn's fatty acid profile and nervonic acid content but did not show effects on visual and cognitive/psychomotor development.