Medin amyloid may drive arterial aging and disease in the periphery and brain.
Medin amyloid may drive arterial aging and disease in the periphery and brain.
复制标题
Medin 淀粉样蛋白可能会导致外周和大脑的动脉老化和疾病。
DOI：
10.1038/s43587-023-00481-3
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Neher,JonasJ
中科院分区：
文献类型：
--
作者：
Madine,Jillian;Davies,HannahA;Migrino,RaymondQ;Ruotsalainen,SanniE;Wagner,Jessica;Neher,JonasJ
衰老是血管疾病的主要风险因素。乳脂球-EGF因子8(MFG-E8)水平升高与许多年龄相关的动脉改变有关，但其机制尚不清楚。我们认为这些有害的影响可能是由Medin引起的，Medin是MFG-E8的一个片段，它形成了一种非常常见的血管淀粉样蛋白。
Aging is a major risk factor for vascular disease. Increased levels of milk fat globule-EGF factor 8 (MFG-E8) are associated with many age-related arterial changes, but the mechanisms remain unclear. We propose that these detrimental effects may result from medin, a fragment of MFG-E8 that forms a highly common vascular amyloid.