Changes in activities of dopamine and serotonin systems in the frontal cortex underlie poor choice accuracy and impulsivity of rats in an attention task
Changes in activities of dopamine and serotonin systems in the frontal cortex underlie poor choice accuracy and impulsivity of rats in an attention task
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DOI：
10.1016/s0306-4522(97)00392-8
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发表时间：
1998-03-01
期刊：
影响因子：
3.3
通讯作者：
Sirviö, J
中科院分区：
文献类型：
--
作者：
Puumala, T;Sirviö, J
本研究的目的是调查是否单胺能系统的功能差异可以解释的变异性，在五个选择系列反应时间任务中的注意缺陷多动障碍模型中测试的大鼠之间的注意力和冲动行为。大鼠在这项任务中保持注意力的能力可以通过测量对视觉刺激的选择准确性（正确反应百分比）来评估，而过早反应的百分比表明冲动的水平。五选择系列反应时任务训练后，大鼠断头取脑进行神经化学测定。多巴胺，去甲肾上腺素，5-羟色胺，多巴胺的代谢产物，3，4-二羟基苯乙酸和高香草酸和5-羟色胺的代谢产物，5-羟吲哚乙酸的水平在额叶皮质，丘脑核，背侧纹状体和海马进行了测定。多元逐步回归分析表明，左额叶皮质5-羟色胺（5-hydroxyindoleacetic acid/5-hydroxytryptamine）和右额叶皮质多巴胺（3，4-dihydroxyphenylacetic acid/dopamine）的利用指数共同解释了被试间注意操作变异的49%。回归分析显示，左额叶皮质5-羟吲哚乙酸/5-羟色胺与选择正确率呈负相关，对侧大脑半球3，4-二羟基苯乙酸/多巴胺比值与选择正确率呈正相关。此外，右额叶皮质5-羟色胺的利用率被发现与过早孔反应的比例呈正相关，这种关系占约24%的变异性，在这个指数的冲动动物之间，这些数据表明，额叶皮质多巴胺和5-羟色胺发挥重要作用，在调制的注意和反应控制。(C)1997年IBRO。出版社：Elsevier Science Ltd
The purpose of the present study was to investigate whether differences in the function of monoaminergic systems could account for the variability in attention and impulsive behaviour between rats tested in the five-choice serial reaction time task in a model of attention deficit hyperactivity disorder. The ability of a rat to sustain its attention in this task can be assessed by measuring choice accuracy (percent correct responses) to visual stimuli, whereas the percentage of premature responses indicates the level of impulsivity. Following training with the five-choice serial reaction time task, rats were decapitated and brain pieces taken for neurochemical determination. Levels of dopamine, noradrenaline, 5-hydroxytryptamine, the dopamine metabolites, 3,4-dihydroxyphenylacetic acid and homovanillic acid and the 5-hydroxytryptamine metabolite, 5-hydroxyindoleacetic acid were determined in the frontal cortex, nucleus accumbens, dorsal striatum and hippocampus. Multivariate regression analysis with a stepwise method revealed that the indeces of utilization of serotonin (5-hydroxyindoleacetic acid/5-hydroxytryptamine) in the left frontal cortex and dopamine (3,4-dihydroxyphenylacetic acid/dopamine) in the right frontal cortex together accounted for 49% of the variability in attentional performance between subjects. According to the regression analysis, a negative correlation existed between the left frontal cortex 5-hydroxyindoleacetic acid/5-hydroxytryptamine and choice accuracy, and a positive correlation was observed between 3,4-dihydroxyphenylacetic acid/dopamine ratio and choice accuracy on the opposite hemisphere. Additionally, right frontal cortex serotonin utilization was found to correlate positively with the proportion of premature hole responses and this relation accounted for about 24% of the variability in this index of impulsivity between animals.These data indicate that frontal cortex dopamine and serotonin play an important role in the modulation of attention and response control. (C) 1997 IBRO. Published by Elsevier Science Ltd.