The ascertainment of multiplex schizophrenia pedigrees from Daghestan genetic isolates (Northern Caucasus, Russia).
The ascertainment of multiplex schizophrenia pedigrees from Daghestan genetic isolates (Northern Caucasus, Russia).
复制标题
达吉斯坦遗传分离株（俄罗斯北高加索）的多重精神分裂症谱系的确定。
DOI：
10.1097/00041444-200010020-00002
复制
发表时间：
2000
影响因子：
0.9
通讯作者：
Byerley,W
中科院分区：
文献类型：
--
作者：
Bulayeva,KB;Leal,SM;Pavlova,TA;Kurbanov,R;Coover,S;Bulayev,O;Byerley,W
本文描述了来自达吉斯坦（北高加索，俄罗斯）孤立山区的多重精神分裂症谱系的初步确定。达吉斯坦有200万人口，有26个土著民族。许多少数民族居住在可以被归类为“初级隔离”的偏远山村。在达吉斯坦，长期的生殖隔离和高原的恶劣环境条件造成了多种多样、基因上孤立的民族人口。该地区的许多分离株包含大量扩展的多重精神分裂症谱系，这是遗传分析的理想选择。在1996年和1997年的夏季考察中，从14个不同的山村确定了14个独立的大型多重精神分裂症谱系。在这14种中，一种有50个精神分裂症病例可供确定，一种有32个，另一种有24个。剩下的7个谱系中有11到23个存活的病例。在同类中，患有慢性精神分裂症的男性人数至少是女性的两倍。近亲婚姻子女精神分裂症的平均发病年龄为21.2岁，非近亲婚姻子女精神分裂症的平均发病年龄为17.4岁（P= 0.033）。虽然从偏远山村确定的家谱可能不能代表一般人群，但它们是绘制精神分裂症易感基因的独特种类。
This article describes the preliminary ascertainment of multiplex schizophrenia pedigrees from the isolated mountain region of Daghestan (Northern Caucasus, Russia). Daghestan has a population of two million people and contains 26 aboriginal ethnic groups. Many of the ethnic groups reside in remote mountain villages that can be classified as ‘primary isolates’. Prolonged reproductive isolation and severe environmental conditions in the highlands have created diverse, genetically isolated ethnic populations in Daghestan. A number of the isolates in this region contain large extended multiplex schizophrenia pedigrees that are ideal for genetic analyses. During summer expeditions of 1996 and 1997, 14 separate large multiplex schizophrenia pedigrees were ascertained from 14 different mountain villages. Of the 14 kindreds, one had 50 schizophrenic cases available for ascertainment, one had 32, and another had 24. Seven of the remaining pedigrees had between 11 and 23 living cases. Within the kindreds, the number of males with chronic schizophrenia was at least twice that of females. The average age of onset of schizophrenia is 21.2 years for offspring of consanguineous marriages and 17.4 years for offspring of nonconsanguineous marriages (P= 0.033). Although the pedigrees ascertained from the remote mountain villages may not be representative of the general population, they are unique kindreds for mapping schizophrenia susceptibility genes.