Two cases of "fulminant" type 1 diabetes suggesting involvement of autoimmunity
Two cases of "fulminant" type 1 diabetes suggesting involvement of autoimmunity
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DOI：
10.1196/annals.1288.059
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发表时间：
2003-01-01
期刊：
影响因子：
--
通讯作者：
Saruta, T
中科院分区：
文献类型：
--
作者：
Nakagawa, Y;Shimada, A;Saruta, T
Recently, a novel subtype of type 1 diabetes, so-called fulminant type 1 diabetes, has been proposed. One of the characteristics of this subtype is the absence of detectable "islet-associated" autoantibody, so it was originally proposed as being "nonautoimmune-mediated"; however, it has not yet been concluded whether autoimmunity is involved. We have previously shown that serum interferon-inducible protein-10 and glutamic acid decarboxylasereactive CD4(+) interferon-gamma-producing cells in the peripheral blood are good markers for T cell-mediated autoimmunity in type 1 diabetes. Here, we report two cases of fulminant type 1 diabetes in which these markers were detected and in which the involvement of islet-associated autoimmunity is suggested.
