Insulin‐like Growth Factor I as an Intraovarian Regulator: Basic and Clinical Implications a
Insulin‐like Growth Factor I as an Intraovarian Regulator: Basic and Clinical Implications a
复制标题
胰岛素样生长因子 I 作为卵巢内调节剂：基本和临床意义
DOI：
--
复制
发表时间：
1991
影响因子：
5.2
通讯作者：
R. Rosenfeld
中科院分区：
文献类型：
--
作者：
E. Adashi;C. Resnick;E. Hernández;A. Hurwitz;C. Roberts;D. Leroith;R. Rosenfeld
虽然关于IGF-I与卵巢生理学的可能相关性仍有许多需要了解的地方，但目前有可能初步阐明IGF-I在这方面的可能功能：1.放大促性腺激素的作用--鉴于卵泡发育的指数性，这是一项关键要求。2.卵泡发育的整合3.优势卵泡的选择(S)--这是一个推测命题，假设“选择的”卵泡中的胰岛素样生长因子-I系统被及时和选择性地激活。胰岛素样生长因子-I(和/或胰岛素样生长因子-II)除了在已建立的卵泡周期中可能起作用(S)外，还可能参与胎儿晚期/新生儿早期卵泡器的形成。虽然当时卵巢是促性腺激素非依赖性的，但我们先前的研究表明，IGF-I可能与现在涉及卵泡器形态分化的VI能输入很好地相互作用。同样，IGF-I可能与促进青少年和青春期早期卵泡促性腺激素(FSH)水平有关；卵巢IGF-I可能与生长激素促进青春期的作用有关。事实上，在啮齿动物和人类受试者中，单独的生长激素缺乏和青春期延迟之间似乎存在关联，这一过程被全身生长激素替代疗法逆转。鉴于卵巢IGF-I及其受体可能是生长激素依赖性的，很容易推测生长激素加速青春期成熟的能力可能至少部分归因于促进卵巢IGF-I的产生和接收，从而局部增强促性腺激素的作用。
Although much remains to be learned with respect to the possible relevance of IGF-I to ovarian physiology, it may be possible at this time to tentatively formulate possible functions of IGF-I in this connection: 1. Amplification of gonadotropin hormonal action--a key requirement given the exponential nature of follicular development. 2. Integration of follicular development--an essential facet concerned with the coordination of granulosa-theca cooperation. 3. Selection of dominant follicle(s)--a speculative proposition assuming timely and selective activation of the IGF-I system in "chosen" follicles. Aside from its possible role(s) in the course of established follicular cycles, IGF-I (and/or IGF-II) may also participate in the very formation of the follicular apparatus during the late fetal/early neonatal period. Although the ovary is gonadotropin-independent at that time, we previously showed that IGF-I may well interact with VIPergic input now implicated in the morphodifferentiation of the follicular apparatus. Similarly, IGF-I may be concerned with the promotion of juvenile and early pubertal follicular gonadotropin (FSH) levels; ovarian IGF-I may have a bearing on the puberty-promoting effect of growth hormone. Indeed, an association appears to exist between isolated growth hormone deficiency and delayed puberty in both rodents and human subjects, a process reversed by systemic growth hormone replacement therapy. Given that ovarian IGF-I and its receptor may be growth hormone-dependent, it is tempting to speculate that the ability of growth hormone to accelerate pubertal maturation may be due, at least in part, to the promotion of ovarian IGF-I production and reception with the consequent local potentiation of gonadotropin action.
登录
查看更多内容
培养的大鼠颗粒细胞中生长调节素-C/胰岛素样生长因子 I 的特定细胞膜受体的表征和调节。
影响因子：
4.8
作者：
Adashi,EY;Resnick,CE;Hernandez,ER;Svoboda,ME;VanWyk,JJ
通讯作者：
VanWyk,JJ
影响因子：
56.9
作者：
RUOSLAHTI, E;PIERSCHBACHER, MD
通讯作者：
PIERSCHBACHER, MD
卵巢卵泡液中的胰岛素样生长因子结合蛋白可阻止卵巢颗粒细胞产生促卵泡激素刺激的类固醇。
影响因子：
4.8
作者：
Ui,M;Shimonaka,M;Shimasaki,S;Ling,N
通讯作者：
Ling,N
影响因子：
4.8
作者：
HSU, CJ;HAMMOND, JM
通讯作者：
HAMMOND, JM
通过释放到培养介质中的胰岛素样生长因子载体蛋白调节胰岛素样生长因子 I 与人成纤维细胞单层培养物的结合。
DOI：
10.1172/jci112343
发表时间：
1986
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
DeVroede,MA;Tseng,LY;Katsoyannis,PG;Nissley,SP;Rechler,MM
通讯作者：
Rechler,MM