Salvianolic acid B suppresses IFN-γ-induced JAK/STAT1 activation in endothelial cells
Salvianolic acid B suppresses IFN-γ-induced JAK/STAT1 activation in endothelial cells
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DOI：
10.1016/j.thromres.2011.08.032
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发表时间：
2011-12-01
影响因子：
7.5
通讯作者：
Cheng, Jing Jy
中科院分区：
文献类型：
--
作者：
Chen, Shih Chung;Lin, Yun Lian;Cheng, Jing Jy
Introduction: Dysfunction of the endotheliumcontributes to pathological conditions of the arterialwall including atherosclerosis as a result of immunological and/or inflammatory responses. Salvianolic acid B (Sal B), a pure and active compound extracted from the Chinese herb Salvia miltiorrhizae (SM) was characterized for its anti-inflammatory and anti-oxidant properties on vascular system.Methods and Results: Sal B pretreatment significantly inhibited the IFN-gamma-induced phosphorylations of JAK2 (Tyr 1007/1008) and STAT1 (Tyr701 and Ser727). Consistently, IFN-gamma-induced STAT1 downstream targets CXC chemokines' IP-10, Mig, and I-TAC were suppressed by Sal B pretreatment. Sal B inhibited promoter activities of IP-10 and the secretion of IP-10 protein. The monocyte adhesion to IFN-gamma-treated ECs was observed to be reduced after Sal B pretreatment. ECs treated with Sal B alone also increased the expression of PIAS1 and SOCS1 which may also contribute to its inhibitory effect on JAK-STAT1 signaling pathways.Conclusions: The anti-inflammatory properties of Sal B on IFN-gamma-induced JAK-STAT1 activation were demonstrated in the present study which provides a molecular basis for possible therapeutic usage on vascular disorders. (C) 2011 Elsevier Ltd. All rights reserved.
