Diet and expression of estrogen alpha and progesterone receptors in the normal mammary gland.
Diet and expression of estrogen alpha and progesterone receptors in the normal mammary gland.
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饮食和正常乳腺中雌激素α和孕激素受体的表达。
DOI：
10.1007/s10552-008-9269-8
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Tr
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作者：
Lagiou,Pagona;Samoli,Evangelia;Lagiou,Areti;Georgila,Christina;Zourna,Pantelina;Barbouni,Anastasia;Gkiokas,George;Vassilarou,Dorothy;Tsikkinis,Annivas;Sfikas,Constantinos;Sekeris,ConstantineE;Hsieh,Chung-Cheng;Adami,Hans-Olov;Tr
目的最近报道，正常乳腺中雌激素α（ER-α）和孕激素（PR）受体的表达与绝经后妇女患乳腺癌的风险呈负相关。我们研究了饮食摄入量是否与表面正常的乳腺组织（而不是病理性乳腺组织）中 ER-α 和 PR 受体的表达相关。方法在希腊的一项研究中，我们研究了饮食摄入量与 562 名乳腺癌（267 名女性）或 BBD（299 名女性）女性的邻近病理性表面正常乳腺组织中 ER-α 和 PR 表达的关系。通过广泛的食物频率调查问卷评估饮食，并使用多元逻辑回归分析结果。结果单不饱和脂质 (p = 0.03) 和较小程度的多不饱和脂质 (p = 0.08) 与 ER-α 表达呈正相关。谷物和淀粉根与 ER-α 呈负相关 (p= 0.01)，而牛奶和乳制品与 PR 表达呈负相关 (p= 0.02)。乙醇摄入量与 ER-α 表达呈非显着负相关 (p=0.07)。结论我们的研究结果表明，饮食与乳腺癌风险的微弱关联在某种程度上可以通过饮食对正常乳腺中受体表达的影响来解释。
ObjectiveIt has been recently reported that expression of estrogen alpha (ER-α) and progesterone (PR) receptors in the normal mammary gland is inversely associated with breast cancer risk among postmenopausal women. We investigated whether dietary intakes are associated with the expression of ER-α and PR receptors in the apparentlynormal, as opposed to pathological, mammary tissue.MethodsIn a study in Greece, we examined associations of dietary intakes with ER-α and PR expression in the adjacent-to-pathological apparently normal mammary tissue of 562 women with either breast cancer (267 women) or BBD (299 women). Diet was assessed through an extensive food frequency questionnaire and results were analyzed using multiple logistic regression.ResultsMonounsaturated (p= 0.03) and, to a lesser extent, polyunsaturated lipids (p= 0.08) were positively associated with ER-α expression. Cereals and starchy roots were inversely associated with ER-α (p= 0.01), whereas milk and dairy products were inversely associated with PR expression (p= 0.02). Ethanol intake was non-significantly inversely associated with ER-α expression (p= 0.07).ConclusionsOur findings suggest that the weak associations of diet with breast cancer risk could be explained, to some extent, by effects of diet on receptor expression in the normal mammary gland.