Scaling Effects on the Electrochemical Stimulation Performance of Au, Pt, and PEDOT:PSS Electrocorticography Arrays
Scaling Effects on the Electrochemical Stimulation Performance of Au, Pt, and PEDOT:PSS Electrocorticography Arrays
复制标题
DOI：
10.1002/adfm.201703019
复制
发表时间：
2017-11-10
影响因子：
19
通讯作者：
Dayeh, Shadi A.
中科院分区：
文献类型：
--
作者：
Ganji, Mehran;Tanaka, Atsunori;Dayeh, Shadi A.
随着更小规模微刺激电极和精细刺激方案的发展，脑电刺激在对抗神经退行性疾病和启动功能方面的有效性有望显著增强。如果不彻底了解对电化学电荷注入特性的标度效应，就不可能实现这些好处。本研究制备并表征了金、铂、聚(3，4-乙二氧基噻吩基)聚苯乙烯磺酸盐(PEDOT：PSS/Au)和直径在20-2000微米范围内的PEDOT：PSS/铂电极阵列的电化学刺激性能。这项研究观察到PEDOT：PSS微电极的电荷注入能力比金属电极高达9.5倍，而注入相同电荷密度所需的功率降低了88%。这些显著的好处在电极直径小于200微米的情况下最为明显。提供了详细的定量分析，从而实现了具有电位偏置的电荷注入能力的优化，以及针对所有直径的对称和非对称脉冲宽度工程。这些系统分析为急性和潜在慢性植入物的最佳设计提供了安全和临床有效的刺激方案，确保电极的寿命低于临界的电化学刺激极限，并证明材料的选择和脉冲设计可以导致更高能效的刺激方案，这对完全植入的设备至关重要。
The efficacy of electrical brain stimulation in combatting neurodegenerative diseases and initiating function is expected to be significantly enhanced with the development of smaller scale microstimulation electrodes and refined stimulation protocols. These benefits cannot be realized without a thorough understanding of scaling effects on electrochemical charge injection characteristics. This study fabricates and characterizes the electrochemical stimulation capabilities of Au, Pt, poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS/Au), and PEDOT:PSS/Pt electrode arrays in the 20-2000 mu m diameter range. This study observes substantial enhancement in charge injection capacity up to 9.5x for PEDOT:PSS microelectrodes compared to metal ones, and 88% lower required power for injecting the same charge density. These significant benefits are strongest for electrode diameters below 200 mu m. Detailed quantitative analyses are provided, enabling optimization of charge injection capacity with potential bias and symmetric and asymmetric pulse width engineering for all diameters. These systematic analyses inform the optimal design for acute and potentially chronic implants in regards to safety and clinically effective stimulation protocols, ensure the longevity of the electrodes below critical electrochemical limits of stimulation, and demonstrate that the material choice and pulse design can lead to more energy efficiency stimulation protocols that are of critical importance for fully implanted devices.