Fatness, fitness, and insulin sensitivity among 7-to 9-year-old children
Fatness, fitness, and insulin sensitivity among 7-to 9-year-old children
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DOI：
10.1038/oby.2007.254
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发表时间：
2007-08-01
期刊：
影响因子：
6.9
通讯作者：
Donnelly, Joseph E.
中科院分区：
文献类型：
--
作者：
Eisenmann, Joe C.;DuBose, Katrina D.;Donnelly, Joseph E.
目的：本研究的目的是探讨肥胖和有氧健身指数的胰岛素抵抗和sensitivity in children.Research Design and Methods之间的关系：共375名儿童（193名女孩和182名男孩）7至9岁的体重分类为正常体重，超重，或肥胖和有氧健身的基础上的次最大体能测试（PWC）。空腹血糖（GLU）和胰岛素（INS）用于计算各种胰岛素敏感性指数（GLU/INS）、稳态模型评估（HOMA）和定量胰岛素敏感性检查指数（QUICKI）。胰岛素生成指数（INS/GLU）和胰岛β细胞功能的HOMA估计值（HOMA %，B）作为胰岛β细胞功能的替代指标。空腹胰岛素（171）、HOMA、QUICKI和INS/GLU在超重和肥胖受试者之间存在显著差异。同样，高健身组具有更好的胰岛素敏感性。一般来说，正常体重高健康组具有最好的胰岛素敏感性，肥胖不健康组具有最差的胰岛素敏感性。六个肥胖组之间存在一些显着差异。特别值得注意的是BMI组内的健身水平和正常体重不适合的科目和超重和肥胖的科目与高fitness.Conclusions之间的值的比较的差异：结果表明，有氧健身衰减的差异，胰岛素敏感性的BMI类别内，从而强调健身的作用，即使在超重和肥胖的儿童。
Objective: The purpose of this study was to examine the relationships among fatness and aerobic fitness on indices of insulin resistance and sensitivity in children.Research Design and Methods: A total of 375 children (193 girls and 182 boys) 7 to 9 years of age were categorized by weight as normal-weight, overweight, or obese and by aerobic fitness based on a submaximal physical working capacity test (PWC). Fasting blood glucose (GLU) and insulin (INS) were used to calculate various indices of insulin sensitivity (GLU/INS), the homeostasis model assessment (HOMA), and the quantitative insulin sensitivity check index (QUICKI). Surrogate measures of pancreatic 0 cell function included the insulinogenic index (INS/GLU) and the HOMA estimate of pancreatic beta-cell function (HOMA %,B).Results: Insulin sensitivity and secretion variables were significantly different between the normal-weight children and the over-weight and obese subjects. Fasting insulin (171), HOMA, QUICKI, and INS/GLU were significantly different between the over-weight and obese subjects. Likewise, the high fitness group possessed a better insulin sensitivity profile. In general, the normal-weight-high fit group possessed the best insulin sensitivity profile and the obese-unfit group possessed the worst insulin sensitivity profile. Several significant differences existed among the six fat-fit groups. Of particular note are the differences within BMI groups by fitness level and the comparison of values between the normal-weight-unfit subjects and the overweight and obese subjects with high fitness.Conclusions: The results indicate that aerobic fitness attenuates the difference in insulin sensitivity within BMI categories, thus emphasizing the role of fitness even among overweight and obese children.