Possible Sources of Endothelin‐1 in Damaged Rat Brain
Possible Sources of Endothelin‐1 in Damaged Rat Brain
复制标题
受损大鼠大脑中内皮素-1 的可能来源
DOI：
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发表时间：
1995
影响因子：
3
通讯作者：
K. Goto
中科院分区：
文献类型：
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作者：
G. Yamada;H. Hama;Y. Kasuya;T. Masaki;K. Goto
本研究探讨了大鼠冷损伤后脑组织中内皮素-1（ET-1）的来源。伤后1-5天伤区ET-1升高。生理学观察表明，发生的血脑屏障的破坏和血浆来源的白蛋白渗出到脑实质后，冷损伤。放射性标记的ET-1注入左心室，在损伤部位的组织中检测到，并且在损伤组织的脑毛细血管中观察到ET-1样免疫反应性。TGF-β1是一种组织再生因子，可诱导培养的星形胶质细胞表达ET-1 mRNA。这些结果表明，ET-1在受损的大脑中通过多种途径产生。
Summary: We investigated the sources of endothelin-1 (ET-1) detected in the damaged brain tissue of rats after cold injury. ET-1 in the injured sites was increased 1–5 days after the injury. Physiologic observations revealed that breakdown of the blood-brain barrier occurred and that plasma-derived albumin exuded into the brain parenchyma after cold injury. Radiolabeled ET-1, which was injected into the left cardiac ventricle, was detected in the tissue at the injury site, and ET-1-like immunoreactivity was observed in the brain capillaries in the damaged tissues. TGF-β1, which is a tissue regeneration factor, potently induced the expression of ET-1 mRNA in cultured astrocytes. These results suggest that ET-1 is produced through a variety of ways in the damaged brain.